59134-90-6

Usage

Uses

Used in Pharmaceutical Applications:
N-(2-Bromo-thiazol-4-yl)-2,2,2-trifluoro-acetamide is used as a potential active pharmaceutical ingredient for its possible antimicrobial, antiviral, and antifungal properties due to the presence of the thiazole ring. The trifluoro-acetamide group may enhance its bioavailability, making it more effective in treating various infections.
Used in Agricultural Applications:
In the agricultural industry, N-(2-Bromo-thiazol-4-yl)-2,2,2-trifluoro-acetamide may be utilized as a bioactive compound with pesticidal properties, leveraging its potential antimicrobial and antifungal activities to protect crops from diseases and pests.

InChI:InChI=1/C5H2BrF3N2OS/c6-4-11-2(1-13-4)10-3(12)5(7,8)9/h1H,(H,10,12)

Upstream product

• 41731-33-3 2-bromo-4-aminothiazole 
• 407-25-0 trifluoroacetic anhydride 
• 41731-35-5 2‐bromo‐1,3‐thiazol‐4‐amine hydrobromide 
• 127-09-3 sodium acetate 

Downstream Products

• 59134-92-8 4-trifluoroacetamidothiazole 

Relevant academic research and scientific papers

Self-assembly of bidentate ligands for combinatorial homogeneous catalysis: Methanol-stable platforms analogous to the adenine-thymine base pair

(Chemical Equation Presented) Complementary partners: A combinatorial library of self-assembled ligand systems has been designed by analogy to the A-T base pair. When these ligand systems are applied in the rhodium-catalyzed hydroformylation of 1-octene (

Mechanism of azo coupling reactions. Part 34. Reactivity of five-membered ring heteroaromatic diazonium ions

The azo coupling reactions of six five-membered heteroaromatic diazonium ions with 2-naphthol-3,6-disulfonic acid are investigated kinetically at various pH values.The dependence of the measured rate constants on the acidity of the aqueous reaction system is evaluated.It can be shown that the 2-naphtholate-3,6-disulfonate trianion reacts 4E8 - 8E8 times faster than the 2-naphthol-3,6-disulfonate dianion.The rate constants of the six diazonium ions vary by more than four orders of magnitude.The logarithms of the rate constants of all comparable diazonium ions correlate linearly with 1H-nmr chemical shifts of the respective unsubstituted heteroaromatic parent compounds.An analogous correlation was found for azo couplings with substituted benzenediazonium ions.Diazotization of heteroaromatic amines does not go to completion, rather to an equilibrium.It is shown therefore that in acidic coupling systems the azo compound is only the kinetically controlled product.The thermodynamic products are 1-nitroso-2-naphthol-3,6-disulfonic acid and the heteroaromatic amine.

Anti-ulcer composition

The invention relates to pharmaceutical compositions for use in treating ulcers or hypersecretion in mammals comprising a compound of formula Ia STR1 WHERE Hal is a halogen atom, R1 is hydrogen or alkyl of 1-6 carbon atoms, R is hydrogen, alkyl of 1-5 carbon atoms (which may be substituted by two or more chlorine or bromine atoms), alkenyl of 2 to 5 carbon atoms, perfluoroalkyl of 1-5 carbon atoms, cycloalkyl of 3 to 5 carbon atoms, R3 is hydrogen, alkyl of 1-6 carbon atoms, or COR4 where R4 is as defined for R and R and R4 may be the same or different, and a pharmaceutically acceptable carrier. Methods of treatment of affected mammals and some novel compounds are also described.

4-Sulfanilamidothiazole

4-Sulfanilamidothiazole having antibacterial activity is prepared from the previously unknown 4-aminothiazole.

4-Aminothiazole

4-Aminothiazole is prepared in stable useful form by alkaline hydrolysis of 4-trifluoroacetamidothiazole. Also prepared are 4-sulfathiazole and 2-(4-thaizolyl)-indazole.