59149-19-8Relevant articles and documents
Discovery and optimization of arylsulfonyl 3-(pyridin-2-yloxy)anilines as novel GPR119 agonists
Zhang, Jian,Li, An-Rong,Yu, Ming,Wang, Yingcai,Zhu, Jiang,Kayser, Frank,Medina, Julio C.,Siegler, Karen,Conn, Marion,Shan, Bei,Grillo, Mark P.,Eksterowicz, John,Coward, Peter,Liu, Jiwen
, p. 3609 - 3613 (2013/07/25)
We describe the discovery of a series of arylsulfonyl 3-(pyridin-2-yloxy) anilines as GPR119 agonists derived from compound 1. Replacement of the three methyl groups in 1 with metabolically stable moieties led to the identification of compound 34, a potent and efficacious GPR119 agonist with improved pharmacokinetic (PK) properties.
Ein einfacher Weg zu Sulfonsaeure-estern aromatischer Amino-hydroxy-Verbindungen unter Anwendung der Phasentransfer-Katalyse
Tappe, Horst
, p. 577 - 578 (2007/10/02)
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