591741-72-9

Upstream product

• 62-53-3 aniline 
• 4916-22-7 methyl 3-phenylaminobut-2-enoate 
• 100-46-9 benzylamine 
• 4916-22-7 methyl (2Z)-3-(phenylamino)but-2-enoate 
• 77320-41-3 2-benzoylamino-3-oxo-butyric acid methyl ester 

Downstream Products

• 787563-24-0 5-methyl-1,2-diphenyl-1H-imidazole-4-carboxylic acid 

Relevant academic research and scientific papers

Electrochemical synthesis of 1,2,4,5-tetrasubstituted imidazoles from enamines and benzylamines

An electrochemical method for synthesizing 1,2,4,5-tetrasubstituted imidazoles was developed under undivided electrolytic conditions. This synthesis was specifically realized based on electrochemical C(sp3)-H aminationviaenamines and amines. Readily available starting materials were used, avoiding the use of both transition metals and oxidants. The practicability of the method lies in its broad substrate adaptability and in its ability to provide a simple green pathway for synthesizing GABAAreceptor analogs.

A concise synthesis of highly substituted imidazoles via copper-mediated oxidative C-H functionalization

We herein report a simple and concise route for the synthesis of highly substituted imidazole derivatives via copper-mediated oxidative C-H functionalization in good to high yields. The advantage of the reaction lies in its mild reaction conditions and readily available starting materials.

FIVE-MEMBERED HETEROCYCLIC DERIVATIVE

The present invention relates to a compound represented by formula (I): a salt of the compound, or a solvate of the compound or the salt; a drug containing any of the compounds, the salts, and the solvates; a preventive and/or therapeutic agent for an ischemic disease containing any of the compounds, the salts, and the solvates; and a platelet coagulation inhibitor containing any of the compounds, the salts, and the solvates. The compound of the present invention is useful as a strong platelet coagulation inhibitor without inhibiting COX-1 or COX-2.

Transformations of methyl 2-benzoylamino-2-oxobutanoate. The synthesis of oxazolo[4,5-c]quinoline and 1-substituted 1H-imidazole-4-carboxylate derivatives

Methyl 2-benzoylamino-2-oxobutanoate (1) was transformed with aromatic amines (2a-d) into methyl 2-arylamino-2-(benzoylamino)but-2-enoates (3a-d) Cyclization of compounds (3a-c) in polyphosphoric acid affords a mixture of oxazolo[4,5-c]quinoline derivatives (4a-c) and 1-aryl-2-phenyl-5 -methyl-1H-imidazole-4-carboxylates (Sa-c), while compound 3d gives a mixture of 9-bromo- (4d) and 7-bromooxazolo[4,5-c]quinoline derivative (4d').