77320-41-3

Basic information

• Product Name: methyl 2-(benzoylamino)-3-oxobutanoate
• CAS NO: 77320-41-3
• Molecular Formula: C₁₂H₁₃NO₄
• Molecular Weight: 235.2359
• Mol File: 77320-41-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 433°C at 760 mmHg
• Flash Point: 215.6°C
• Density: 1.195g/cm³
• Vapor Pressure: 1.06E-07mmHg at 25°C
• Refractive Index: 1.523
• CAS DataBase Reference: methyl 2-(benzoylamino)-3-oxobutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(benzoylamino)-3-oxobutanoate(77320-41-3)
• EPA Substance Registry System: methyl 2-(benzoylamino)-3-oxobutanoate(77320-41-3)

Safety Data

• Hazardous Substances Data: 77320-41-3(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 37127-06-3 2-phenyl-4-acetyl-5-oxazolinone 
• 98-88-4 benzoyl chloride 
• 87413-09-0 Dess-Martin periodane 
• 24762-04-7 2-Diazo-3-oxo-butyric acid methyl ester 
• 55-21-0 benzamide 
• 41172-77-4 (±)-2-amino-3-oxo-butyric acid methyl ester hydrochloride 
• 495-69-2 Hippuric Acid 
• 124576-57-4 C₁₀H₁₇NO₅ 
• 68277-01-0 2-amino-3-oxo-butyric acid methyl ester 
• 79893-89-3 N-benzoyl-L-threonine methyl ester 
• 1205-08-9 methyl hippurate 
• 75-36-5 acetyl chloride 
• 99972-61-9 2-phenyl-4-α-hydroxyethylidene-5-oxazolone 

Downstream Products

• 18735-74-5 5-methyl-2-phenyloxazole-4-carboxylic acid 
• 591741-72-9 methyl 5-methyl-1,2-diphenyl-1H-imidazole-4-carboxylate 
• 79893-89-3 N-benzoyl-L-threonine methyl ester 
• 60538-16-1 (2R,3S)-N-benzoylthreonine methyl ester 

Relevant articles and documents

Transformation of 4-(1-dimethylaminoethylidene)-2-phenyl-5(4H) oxazolone into methyl 2-benzoylamino-3-oxobutanoate. The synthesis of 1-substituted 4- benzoylamino-3-methyl-5(2H)-pyra-zolones

Methyl 2-benzoylamino-3-oxobutanoate (3) was prepared from hippuric acid (1) which was converted with N,N-dimethylacetamide and phosphorus oxychloride into 4-(1-dimethylaminoethylidene)-2-phenyl-5(4H)-oxazolone (2) followed by hydrolysis with hydrochloric acid in methanol. Compound 3 was treated with hydrazines 4 to give 4-benzoylamino-3-methyl-1H-pyrazol-5(2H)-one (6a) and its 1-substituted derivatives 6b-j. The corresponding hydrazones 5f, i, j were isolated as intermediates.

The rhodium carbene route to oxazoles: A remarkable catalyst effect

Dirhodium tetraacetate catalysed reaction of α-diazo-β-keto- carboxylates and -phosphonates with arenecarboxamides gives 2-aryloxazole-4- carboxylates and 4-phosphonates by carbene N-H insertion and cyclodehydration; in stark contrast, dirhodium tetrakis(

Pd-catalyzed enantioselective synthesis of quaternary α-amino acid derivatives using a phenylalanine-derived P-chirogenic diaminophosphine oxide

A Pd-catalyzed enantioselective synthesis of quaternary α-amino acid derivatives using a phenylalanine-derived P-chirogenic diaminophosphine oxide is described. Asymmetric allylic substitution using acyclic β-keto esters with a nitrogen functional group at the α-carbon as prochiral nucleophiles proceeded in the presence of 5 mol % of Pd catalyst, 10 mol % of chiral diaminophosphine oxide 1j, BSA, and appropriate additives, affording the corresponding quaternary α-amino acid derivatives in excellent yield and in up to 92% ee.