591755-15-6Relevant articles and documents
Synthesis and evaluation of new 4(3H)-Quinazolinone derivatives as potential anticancer agents
Gatadi, Srikanth,Pulivendala, Gauthami,Gour, Jitendra,Malasala, Satyaveni,Bujji, Sushmitha,Parupalli, Ramulu,Shaikh, Mujahid,Godugu, Chandraiah,Nanduri, Srinivas
, (2019/09/30)
A series of new 4(3H)-quinazolinones were synthesized and evaluated for their cytotoxic activity against a set of human cancer cell lines MDA-MB-231 and MCF-7 (breast), HCT-116 and HT-29 (colon) and A549 (lung). Among the tested compounds, 22a exhibited p
Mimicking the intramolecular hydrogen bond: Synthesis, biological evaluation, andmolecular modeling of benzoxazines and quinazolines as potential antimalarial agents
Gemma, Sandra,Camodeca, Caterina,Brindisi, Margherita,Brogi, Simone,Kukreja, Gagan,Kunjir, Sanil,Gabellieri, Emanuele,Lucantoni, Leonardo,Habluetzel, Annette,Taramelli, Donatella,Basilico, Nicoletta,Gualdani, Roberta,Tadini-Buoninsegni, Francesco,Bartolommei, Gianluca,Moncelli, Maria Rosa,Martin, Rowena E.,Summers, Robert L.,Lamponi, Stefania,Savini, Luisa,Fiorini, Isabella,Valoti, Massimo,Novellino, Ettore,Campiani, Giuseppe,Butini, Stefania
, p. 10387 - 10404 (2013/02/23)
The intramolecular hydrogen bond formed between a protonated amine and a neighboring H-bond acceptor group in the side chain of amodiaquine and isoquine is thought to play an important role in their antimalarial activities. Here we describe isoquine-based
