591769-90-3

Basic information

• Product Name: 3(2H)-Pyridazinone, 4,5-bis(4-chlorophenyl)-
• CAS NO: 591769-90-3
• Molecular Formula: C16H10Cl2N2O
• Molecular Weight: 317.174
• Mol File: 591769-90-3.mol

Chemical Properties

• CAS DataBase Reference: 3(2H)-Pyridazinone, 4,5-bis(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3(2H)-Pyridazinone, 4,5-bis(4-chlorophenyl)-(591769-90-3)
• EPA Substance Registry System: 3(2H)-Pyridazinone, 4,5-bis(4-chlorophenyl)-(591769-90-3)

Safety Data

• Hazardous Substances Data: 591769-90-3(Hazardous Substances Data)

Upstream product

• 1679-18-1 4-Chlorophenylboronic acid 
• 51355-97-6 4,5-dichloro-2-(hydroxymethyl)pyridazin-3(2H)-one 
• 856250-23-2 2-benzyl-4,5-bis(4-chlorophenyl)pyridazin-3(2H)-one 

Downstream Products

• 856250-24-3 3-chloro-4,5-bis(4-chlorophenyl)pyridazine 

Relevant articles and documents

Pyridazines. Part 34: Retro-ene-assisted palladium-catalyzed synthesis of 4,5-disubstituted-3(2H)-pyridazinones

The efficient one-pot bis-functionalization of the 4,5-positions of the 3-pyridazinone ring has been performed using Suzuki, Sonogashira and Stille cross-coupling reactions assisted by a retro-ene fragmentation. This route allows access in a shorter synthetic sequence to several pharmacologically useful 3(2H)-pyridazinones.

Azabicyclic heterocycles as cannabinoid receptor modulators

The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the general Formula I: including all prodrugs, pharmaceutically acceptable salts and stereoisomers, R1, R2, R3, R6, R7, m and n are described herein.

Pyridazines. Part 35: Traceless solid phase synthesis of 4,5- and 5,6-diaryl-3(2H)-pyridazinones

A new method for the traceless solid phase synthesis of 3(2H)-pyridazinones has been developed employing dihydropyran-functionalized resin. The procedure has permitted the preparation of several diarylpyridazinones through a Suzuki cross-coupling reaction and cleavage conditions that promoted a retro-ene fragmentation.