59177-47-8Relevant articles and documents
Synthesis and in vitro antibacterial activity of new 2-(1-methyl-4-nitro- 1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles
Letafat, Bahram,Mohammadhosseini, Negar,Asadipour, Ali,Foroumadi, Alireza
, p. 1120 - 1123 (2011)
In the present study we report the synthesis and antibacterial activity of a new series 2-(1-methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles (6a-c). Compounds 6a-c were tested in vitro by the conventional agar dilution method against a panel of microorganisms including gram-negative and gram-positive bacteria. Compound 6b with 5-(5-nitrofuran-2-yl)-residue on 1,3,4-thiadiazole scaffold have shown promising antibacterial activities against gram-positive bacteria including Staphylococcus aureus, Staphylococcus epidermidis and Bacillus subtilis.
Synthesis and In-vitro antibacterial activity of 5-substituted 1-methyl-4-nitro-1H-imidazoles
Letafat, Bahram,Emami, Saeed,Aliabadi, Alireza,Mohammadhosseini, Negar,Moshafi, Mohammad Hassan,Asadipour, Ali,Shafiee, Abbas,Foroumadi, Alireza
body text, p. 497 - 501 (2009/04/04)
A series of 5-substituted 1-methyl-4-nitro-1H-imidazole derivatives were synthesized and evaluated for in-vitro antibacterial activity against a panel of microorganisms including Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, Esherichia coli, Klebsiella pneumonia, Entrobacter aerogenes, and Helicobacter pylori using conventional agar dilution method. Among the test compounds, 1-methyl-4-nitro-5-(phenylsulfonyl)-1H-imidazole was the most potent against Gram-positive bacteria, with a MIC value of ≤8 μg/mL. All compounds showed no significant activity against Gram-negative bacteria at concentrations ≤64 μg/mL The MIC values against 15 clinical isolates of H. pylori indicated that compounds 10 and 11 were the most active compounds in this series in terms of inhibiting the growth of H. pylori (MIC = 2 μg/mL). It was also demonstrated that their corresponding activities were four times larger than that of metronidazole.
A New and Unequivocal Method for Establishing the Position of N-Glycosylation of Unsymmetrically C-Substituted Imidazoles
Benson, Timothy J.,Robinson, Brian
, p. 211 - 214 (2007/10/02)
N-Substitution of an unsymmetrically C-substituted imidazole can give rise to a pair of structurally isomeric derivatives and to differentiate between such related compounds can be difficult.Two methods, one spectroscopic and one chemical, for ascertaining the orientation of such N-substitutions are described, with particular application to the establishment of the direction of N-ribosidation of a series of halogeno nitroimidazoles.