5918-66-1Relevant academic research and scientific papers
Ultrasound-assisted synthesis, anticonvulsant activity, and docking study of indole-appended thiazolidin-4-ones
Nikalje, Anna Pratima G.,Shaikh, Sameer I.,Mulay, Abhineet,Khan, Firoz A. K.,Sangshetti, Jaiprakash N.,Shaikh, Shoaib
, p. 756 - 767 (2016/02/26)
Two series of novel indolyl thiazolidin-4-one derivatives 4a-j and 5a-j were obtained by an ecofriendly synthetic protocol by treating a mixture of Schiff's bases (0.01 mol) with thioglycolic acid or thiolactic acid (0.01 mol) and anhydrous zinc chloride
Synthesis, characterization and biological activity of Schiff base analogues of indole-3-carboxaldehyde
Sinha, Deepa,Tiwari, Anjani K.,Singh, Sweta,Shukla, Gauri,Mishra, Pushpa,Chandra, Harish,Mishra, Anil K.
, p. 160 - 165 (2008/09/17)
Eight novel heterocyclic Schiff bases derived from the condensation reactions of indole 3-carboxaldehyde with different l-amino acids (histidine, glutamic acid, aspartic acid, leucine, valine) as well as with some aminophenols, have been synthesized and characterized by various spectroscopic methods (IR, MS, 1H NMR). Schiff base derivatives of indole 3-carboxaldehyde were labeled with 99mTc and radiochemical purity was above 97% which is ascertained by instant thin layer chromatography using different solvent conditions. Stability studies of all the derivatives of indole 3-carboxaldehyde was determined under physiological conditions and were stable for more than 24 h. Blood clearance showed a quick wash out from the circulation and biological half life was found to be t1/2(F) = 1 h 15 min; t1/2(S) = 10 h 05 min. Excellent quality radioimages of tumor bearing mice were recorded showing rapid clearance of background activity, visualization of tumor at 3 h and clearance from kidneys of histidine analogue which was further evidenced in biodistribution studies. Antimicrobial activity of these Schiff base compounds was evaluated against Bacillus subtilis, Pseudomonas fluorescence, Staphylococcus aureus, Aspergillus niger, Candida albicans and Trichophyton rubrum.
