5918-77-4

Upstream product

• 504-29-0 2-aminopyridine 
• 555-16-8 4-nitrobenzaldehdye 
• 23574-81-4 N-(triphenylphosphoranylidene)pyridin-2-amine 

Downstream Products

• 42178-54-1 N,N'-p-Nitrobenzyliden-bis(2-aminopyridin) 
• 79202-14-5 diethyl phosphonate 
• 7498-40-0 4-nitro-N-pyridine-2-yl-benzamide 
• 555-16-8 4-nitrobenzaldehdye 
• 65838-46-2 (1E,1'E)-N,N'-(ethane-1,2-diyl)bis(1-(4-nitrophenyl)methanimine) 
• 897664-58-3 (E,E)-N,N'-bis(4-nitrobenzylidene)hexane-1,4-diamine 
• 13313-19-4 (4-nitro-benzylidene)-[3]pyridyl-amine 

Relevant academic research and scientific papers

Synthesis and molecular docking studies of imines as α-glucosidase and α-amylase inhibitors

Imine functionality is found in many compounds with important biological activity. Thus, the development of novel synthetic approaches for imines is important. In this work, it is propose an easy, eco-friendly and straightforward synthesis pathway of aryl imines under microwave irradiation catalyzed by Alumina-sulfuric acid. In addition, the in vitro enzymatic inhibition, antioxidant activity and molecular docking studies were performed. The aryl imines were isolated with yields in the range of 37–94%. All aryl imines synthesized were evaluated for in vitro inhibitory potential against α-glucosidase and α-amylase enzymes and the results exhibited that the most of the compounds displayed inhibitory activity against both enzymes. The (E)-1-(4-nitrophenyl)-N-(pyridin-2-yl)methanimine (3d) was 1.15-fold more active than acarbose against α-amylase whilst the (E)-1-phenyl-N-(pyridin-2-yl)methanimine (3c) displayed similar activity that acarbose against α-glucosidase. The molecular docking studies in α-glucosidase and α-amylase reveal that aryl imines mainly establish an H-bond with the R2-subtituent and hydrophobic interactions with the R1-subtituent. The docking analysis reveals these synthetic aryl imines 3d-i interact in same active site than acarbose drug in both enzymes.

Synthesis, antimicrobial screening, homology modeling, and molecular docking studies of a new series of Schiff base derivatives as prospective fungal inhibitor candidates

Twelve new Schiff base derivatives have been prepared by the condensation reaction of different amino substituted compounds (aniline, pyridin-2-amine, o-toluidine, 2-nitrobenzenamine, 4-aminophenol, and 3-aminopropanol) and substituted aldehydes such as n

INVERSE ELECTRON DEMAND DIELS-ALDER REACTION OF 2-(ARYLMETHYLENEAMINE)-PYRIDINES WITH ENAMINES AND STYRENES. SYNTHESIS OF PYRAMIDINE DERIVATIVES

The reaction of 2-(arylmethyleneamino)-pyridines bearing an electron withdrawing group on the arylmethylene moiety 1 a, b and 2 a, b as heterodienes, with enamines 3 a, b or styrenes 4 a, b as dienophiles, affords, the corresponding pyrimidines by means o

Studies on the Oxidation of the Azomethine Compounds with 3-Chloroperbenzoic Acid

Oxidation of the azomethine compounds such as Schiff bases and azines having several nucleophilic centers with 3-chloroperbenzoic acid (MCPBA) being an electrophilic oxidant was investigated.From azines 4, bisaldimines 5, 6, and pyridine derived monoaldimines 7, 8, having various substituents on the imine carbon and nitrogen atoms, the products such as nitrones 9, 15, bisoxaziridines 11, 12; acyldiimine 10 and amide 14 were obtained in high yields.The influence of the structure of substrate on the reaction result is discussed.Key words: aldimines, azines, nitrones, oxaziridines

NEW SYNTHETIC METHODOLOGY FOR THE PREPARATION OF SUBSTITUTED 1-ARYL-1-PYRIDYLAMINOMETHANEPHOSPHONIC ACID ESTERS

Esters of 1-phenyl-1-pyridylaminomethanephosphonates generally cannot, or only in poor yields be prepared by the usual methods by treatment of the appropriate Schiff base with diethyl or diphenyl phosphite.However, it was found that these phosphonates are

Co-condensation of 2-Aminopyridine, Aromatic Aldehydes, and Ketones

The co-condensation of 2-aminopyridine with aromatic aldehydes and ketones proceeds via the initial formation from the amine and the benzaldehydes of (2-pyridylamino)aryl carbinols, which then react with p-nitroacetophenone to give 3-aryl-1-(4-nitrophenyl