59189-51-4

Usage

Chemical Properties

colorless to pale yellow crystalline low melting

InChI:InChI=1/C13H8F2O/c14-10-7-4-8-11(15)12(10)13(16)9-5-2-1-3-6-9/h1-8H

Upstream product

• 1897-52-5 2,6 difluorobenzonitrile 
• 80-17-1 benzenesufonyl hydrazide 
• 108-86-1 bromobenzene 
• 1421364-35-3 (2,6-difluorophenyl)diphenylmethanol 
• 372-18-9 1,3-Difluorobenzene 
• 98-88-4 benzoyl chloride 
• 98-80-6 phenylboronic acid 

Downstream Products

• 153877-55-5 (2,6-difluorophenyl)(phenyl)methanol 
• 1242146-60-6 [Co(Me)F(2-(6-FC₆H₃)C(=O)C₆H₅)(PMe₃)2] 
• 1314792-49-8 (2-benzoyl-3-fluorophenyl)phenylthioether 
• 1421364-35-3 (2,6-difluorophenyl)diphenylmethanol 
• 119-61-9 benzophenone 
• 1423172-34-2 C₃₂H₃₄F₂FeO₂P₂ 
• 1204771-71-0 C₁₇H₁₀FN₃O₂S 
• 1569280-29-0 C₁₃H₉FN₂ 
• 1569280-39-2 C₁₉H₁₄FN₃O₂S 

Relevant academic research and scientific papers

Preparation method of aromatic ketone

The invention discloses a preparation method of aromatic ketone. Under the effects of a palladium catalyst and a nitrogen-containing ligand, nitrile compounds and arylsulfonylhydrazide take desulfurization addition reaction in an organic solvent; after the reaction is completed, post treatment is performed to obtain aromatic ketone. The reaction is applicable to aromatic nitrile compounds, and isalso applicable to aliphatic nitrile compounds; the reaction realizes the wide substrate applicability and functional group tolerance; the potential application value is realized in the aspect of aryl-carbonyl building.

Pd(II)-Catalyzed Denitrogenative and Desulfinative Addition of Arylsulfonyl Hydrazides with Nitriles

A Pd(II)-catalyzed denitrogenative and desulfinative addition of arylsulfonyl hydrazides with nitriles has been successfully achieved under mild conditions. This transformation is a new method for the addition reaction to nitriles with arylsulfonyl hydrazides as arylating agent, thus providing an alternative synthesis of aryl ketones. The reported addition reaction is tolerant to many common functional groups, and works well in the presence of electron-donating and electron-withdrawing substituents. Notably, the reported denitrogenative and desulfinative addition was also appropriate for alkyl nitriles, making this newly developed transformation attractive.

Sodiation of Arenes and Heteroarenes in Continuous Flow

The first sodiations of (hetero)arenes in continuous flow using NaDA (sodium diisopropylamide) in Me2EtN are reported. This flow procedure enables sodiation of functionalized arenes and heteroarenes that decompose under batch-sodiation conditions. The resulting sodiated (hetero)arenes react instantly with various electrophiles, such as ketones, aldehydes, isocyanates, alkyl bromides, and disulfides, affording polyfunctionalized (hetero)arenes in high yields. Scale-up is possible without further optimization.

Steric and electronic effects influencing β-aryl elimination in the Pd-catalyzed carbon-carbon single bond activation of triarylmethanols

An analysis of the palladium-catalyzed activation of carbon-carbon single bonds within triarylmethanols has led to a greater understanding of factors influencing the β-aryl elimination process responsible for C-C bond cleavage. A series of competition reactions were utilized to determine that β-aryl elimination of aryl substituents containing ortho-substitution proceeds with significant preference to unsubstituted phenyl rings. Further experiments indicate that substrates containing either strongly donating or withdrawing substituents are cleaved from triarylmethanols more readily than relatively neutral species.

Direct zincation of functionalized aromatics and heterocycles by using a magnesium base in the presence of ZnCl2

A wide range of polyfunctional aryl and heteroaryl zinc reagents were efficiently prepared in THF by using (TMP)2:Mg·2LiCl (TMP = 2,2,6,6-tetramethylpiperamidyl) in the presence of ZnCl2. The possible pathways of this metalation proc

Palladium(II)-catalyzed addition of arylboronic acid to nitriles

The addition of arylboronic acid to nitriles catalyzed by palladium(II) species in the presence of bipyridine as the ligand was developed. The use of bipyridine is crucial for changing the properties of arylpalladium species from more electrophilic to more nucleophilic making the reaction possible.