59216-21-6Relevant articles and documents
Dihydrazone compound high in affinity with Abeta protein and Tau protein, derivative thereof, and applications of dihydrazone compound and derivative
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Paragraph 0080-0082; 0158-0160, (2019/05/15)
The invention provides a dihydrazone compound high in affinity with Abeta protein and Tau protein, a derivative thereof, and applications of the dihydrazone compound and the derivative. The structureof the dihydrazone compound is represented by formula I. The dihydrazone compound can be directly taken as a fluorescence probe used for detecting neurofibrillary tangles in vivo or in tissue samples;when the dihydrazone compound is adopted in nuclear medicine imaging, appropriate radioisotopes are needed for labeling. The dihydrazone compound is especially suitable to be used for diagnosis of neurodegenerative diseases, and diagnosis of patients with diseases with Abeta plaques including Alzheimer's disease.
Ultraviolet absorption spectra of ortho-hydroxyaromatic aldehyde para-substituted benzylidenehydrazones (author's transl)
Ogawa,Ono,Ueda
, p. 44 - 52,46,52 (2007/10/13)
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