3291-00-7Relevant academic research and scientific papers
A coumarin-based sensitive and selective fluorescent sensor for copper(II) ions
Yeh, Jiun-Ting,Chen, Wei-Chieh,Liu, Shi-Rong,Wu, Shu-Pao
, p. 4434 - 4439 (2014)
A new coumarin-derived fluorescent probe (1) exhibited significant fluorescence quenching in the presence of Cu2+ ions. Other metal ions, e.g. Ag+, Ca2+, Cd2+, Co2+, Fe2+, Fe3+, Hg2+, K+, Mg 2+, Mn2+, Ni2+, Pb2+, and Zn 2+, produced only minor changes in the fluorescence of chemosensor 1. The binding ratio of the chemosensor-Cu2+ complexes was found to be 2 : 1, according to Job plot experiments. The association constant (K a) for Cu2+ binding with chemosensor 1 was found to be 9.56 × 109 M-2. The maximum fluorescence quenching caused by Cu2+ binding with chemosensor 1 occurred over a pH range of 5-9. Moreover, fluorescence microscopy experiments showed that chemosensor 1 could be used as a fluorescent probe for detecting Cu2+ in living cells. the Partner Organisations 2014.
Structure investigation of three hydrazones Schiff's bases by spectroscopic, thermal and molecular orbital calculations and their biological activities
Belal, Arafa A.M.,Zayed,El-Desawy,Rakha, Sh.M.A.H.
, p. 49 - 57 (2015)
Three Schiff's bases AI (2(1-hydrazonoethyl)phenol), AII (2, 4-dibromo 6-(hydrazonomethyl)phenol) and AIII (2(hydrazonomethyl)phenol) were prepared as new hydrazone compounds via condensation reactions with molar ratio (1:1) of reactants. Firstly by reaction of 2-hydroxy acetophenone solution and hydrazine hydrate; it gives AI. Secondly condensation between 3,5-dibromo-salicylaldehyde and hydrazine hydrate gives AII. Thirdly condensation between salicylaldehyde and hydrazine hydrate gives AIII. The structures of AI-AIII were characterized by elemental analysis (EA), mass (MS), FT-IR and 1H NMR spectra, and thermal analyses (TG, DTG, and DTA). The activation thermodynamic parameters, such as, ΔE?, ΔH?, ΔS? and ΔG? were calculated from the TG curves using Coats-Redfern method. It is important to investigate their molecular structures to know the active groups and weak bond responsible for their biological activities. Consequently in the present work, the obtained thermal (TA) and mass (MS) practical results are confirmed by semi-empirical MO-calculations (MOCS) using PM3 procedure. Their biological activities have been tested in vitro against Escherichia coli, Proteus vulgaris, Bacillissubtilies and Staphylococcus aurous bacteria in order to assess their anti-microbial potential.
Salicylhydrazone ligands for enantioselective addition of diethylzinc to aldehydes
Arai, Takayoshi,Endo, Yoko,Yanagisawa, Akira
, p. 165 - 169 (2007)
A family of chiral salicylhydrazones was designed and synthesized for application in asymmetric catalysis. The ability of newly prepared binaphthyl-containing salicylhydrazones as the chiral ligand was examined in the addition of diethylzinc to aldehyde, with the desired product obtained in up to 80% ee.
An azine based sensor for selective detection of Cu2 + ions and its copper complex for sensing of phosphate ions in physiological conditions and in living cells
Tiwari, Karishma,Kumar, Sumit,Kumar, Vipan,Kaur, Jeevanjot,Arora, Saroj,Mahajan, Rakesh Kumar
, p. 16 - 26 (2018)
A simple and cost effective unsymmetrical azine based Schiff base, 5-diethylamino-2-[(2-hydroxy-benzylidene)hydrazonomethyl]-phenol (1) was synthesized which selectively detect Cu2 + ions in the presence of other competitive ions through “naked eye” in physiological conditions (EtOH–buffer (1:1, v/v, HEPES 10 mM, pH = 7.4)). The presence of Cu2 + induce color change from light yellow green to yellow with the appearance of a new band at 450 nm in UV–Vis spectra of Schiff base 1. The fluorescence of Schiff base 1 (10 μM) was quenched completely in the presence of 2.7 equiv. of Cu2 + ions. Sub-micromolar limit of detection (LOD = 3.4 × 10? 7 M), efficient Stern–Volmer quenching constant (KSV = 1.8 × 105 L mol? 1) and strong binding constant (log Kb = 5.92) has been determined with the help of fluorescence titration profile. Further, 1 ? Cu2 + complex was employed for the detection of phosphate ions (PO43 ?, HPO42 ? and H2PO4?) at micromolar concentrations in EtOH–buffer of pH 7.4 based on fluorescence recovery due to the binding of Cu2 + with phosphate ions. Solubility at low concentration in aqueous medium, longer excitation (406 nm) and emission wavelength (537 nm), and biocompatibility of Schiff base 1 formulates its use in live cell imaging.
Synthesis and characterization of hydrazone and azine derivatives of bis(cyclopentadienyI) titanium(IV)
Kaushik, Narender Kumar,Khera, Brij,Sharma, Anand Kumar
, p. 793 - 794 (2021/11/22)
Pentacoordinated hydrazone and azine derivatives of bis(cyclopentadienyl)titanium(IV) of the type {equation presented}, have been prepared. The products were characterized by chemical analyses, elec- trical conductance, IR, 1H NMR, and electronic spectral studies. Some hydrazone complexes and a few azine com- plexes of titanium have been studied.' ' However, no systematic study on their organometallic derivatives is available. In view of the versatile chelating ability, widespread applications and lack of data involving organometallic derivatives of titanium, it has been considered of interest to study the reactions of Cp2TiCl2 with the title ligands.
Fluorescent molecule, preparation method thereof, application thereof and fluorescence detection reagent (by machine translation)
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Paragraph 0092; 0103-0106; 0111; 0117, (2019/12/02)
The invention discloses a fluorescent molecule, a preparation method thereof, an application thereof and a fluorescence detection reagent. A fluorescent molecule, which is a compound having the structure represented (1) by the following formula: wherein the compound is (1) as follows. In-flight vehicle R1 Alkyl group or substituted aromatic group and R group thereof2 A substituted aromatic group containing a-N&S * FF1D;N-N&S * FF1D;CH-group. -Né N-N&S * FF1D; N-N&S * FF1D; CH-group can specifically interact with hypochlorous acid, so that it can have naked eye recognition capability on hypochlorous acid, and simultaneously, the hypochlorite ion can be accurately, sensitively, specifically and efficiently detected. (by machine translation)
Red-emitting salicylaldehyde Schiff base with AIE behaviour and large Stokes shift
Gong, Junyi,Wei, Peifa,Su, Yuanan,Li, Ying,Feng, Xing,Lam, Jacky W.Y.,Zhang, Dongzhou,Song, Xiangzhi,Tang, Ben Zhong
, p. 1493 - 1496 (2018/06/18)
Three salicylaldehyde Schiff base (SSB), iso-PBP, PBP and EPB, were facilely synthesized and exhibited aggregation-induced emission. The introduction of C = N-N = C moiety in these SSB dyes largely extend the conjugation system and push their emission to yellow to red spectral region. These SSB dyes were negligibly fluorescent in dilute THF solution. In THF/water mixtures with high water fractions, they displayed strong yellow to red fluorescence (up to 617 nm) and large Stokes shifts (up to 152 nm). Single crystal analysis on EBP showed the longer emission of in aggregated state was attributed to the molecular packing effect as compared with that in dilute solution. The bio-imaging application indicated EBP could specifically accumulate in lipid droplets in living cells.
Impact of various lipophilic substituents on ruthenium(II), rhodium(III) and iridium(III) salicylaldimine-based complexes: synthesis, in vitro cytotoxicity studies and DNA interactions
Cassells, Irwin,Stringer, Tameryn,Hutton, Alan T.,Prince, Sharon,Smith, Gregory S.
, p. 763 - 774 (2018/06/06)
Abstract: A series of bidentate salicylaldimine ligands was prepared and reacted with either [RuCl(μ-Cl)(p-cymene)]2, [RhCl(μ-Cl)(Cp*)]2 or [IrCl(μ-Cl)(Cp*)]2. All of the compounds were characterised using an array of spectroscopic and analytical techniques, namely, nuclear magnetic resonance (NMR) spectroscopy, infrared (IR) spectroscopy and mass spectrometry. Single crystal X-ray diffraction (XRD) was used to confirm the bidentate coordination mode of the salicylaldimine ligand to the metal centre. The platinum group metal (PGM) complexes were screened against the MCF7 breast cancer cell line. The ruthenium and iridium salicylaldimine complexes showed comparable or greater cytotoxicity than cisplatin against the MCF7 cancer cells, as well as greater cytotoxicity than their rhodium counterparts. Three of the salicylaldimine complexes showed potent activity in the range 18–21?μM. Two of these complexes had a greater affinity for cancerous cells than for CHO non-cancerous cells (SI > 4). Preliminary mechanistic studies suggest that the ruthenium complexes undergo solvation prior to 5′-GMP binding, whereas the iridium complexes were inert to the solvation process. Graphical abstract: [Figure not available: see fulltext.].
Rhodium-catalysed hydroformylation of 1-octene using aryl and ferrocenyl Schiff base-derived ligands
Siangwata, Shepherd,Chulu, Sisasenkosi,Oliver, Clive L.,Smith, Gregory S.
, (2017/03/24)
Monometallic and heterobimetallic complexes of Rh(I) bearing chelating N,O-bidentate aryl- and ferrocenyl-derived ligands have been synthesised via Schiff base condensation reactions, and characterised fully using 1H NMR, 13C{1H} NMR and Fourier transform infrared spectroscopies, elemental analysis and mass spectrometry. The new monometallic and heterobimetallic complexes were evaluated as potential catalyst precursors in the hydroformylation of 1-octene at 95°C and 40?bar. The ferrocenylimine mononuclear compounds were inactive in the hydroformylation experiments. The Rh(I) monometallic and the ferrocene–Rh(I) heterobimetallic pre-catalysts displayed good activity and conversion of 1-octene as well as outstanding chemoselectivity towards aldehydes in the hydroformylation reaction.
A naphthalimide-based solid state luminescent probe for ratiometric detection of aluminum ions:: In vitro and in vivo applications
Gupta, Neha,Kaur, Taranjeet,Bhalla, Vandana,Parihar, Ripu D.,Ohri, Puja,Kaur, Gurcharan,Kumar, Manoj
supporting information, p. 12646 - 12649 (2017/12/02)
A naphthalimide-based fluorescent probe 4 has been designed and synthesized that detects Al3+ ions in solution, solid state and in biological systems, including cells, tissues and nematodes. Further, a portable kit has been developed using probe 4 for the on-site detection of Al3+ ions.
