59223-84-6

Upstream product

• 3235-26-5 2-(N-acetylamino)-2-benzylpropanedioic diethyl ester 
• 518314-53-9 2-(N-(tert-butoxycarbonyl)amino)-2-benzylpropanedioic diethyl ester 
• 102831-44-7 diethyl tert-butoxycarbonylaminomalonate 
• 6829-40-9 aminomalonic acid diethyl ester 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 

Downstream Products

• 6613-41-8 ethyl 3-phenylpyruvate 
• 59223-92-6 2-acetoxy-2-acetylamino-3-phenyl-propionic acid ethyl ester 
• 211301-12-1 2-Acetylamino-2-benzyl-N-benzyloxy-malonamic acid ethyl ester 
• 2361-96-8 ethyl N-acetyl-(L)-phenylalaninate 
• 2361-96-8 (R)-ethyl N-acetylphenylalanine 
• 4134-09-2 ethyl N-acetyl-DL-phenylalaninate 
• 66569-36-6 N-Acetyl-2-benzylthiophenylalaninaethylester 
• 70962-86-6 2-Acetylamino-2-(4-methoxy-phenyl)-3-phenyl-propionic acid ethyl ester 
• 211301-25-6 2-Acetylamino-2-benzyl-N-benzyloxy-malonamic acid 
• 59223-89-1 2-Acetylamino-2-ethoxy-3-phenyl-propionic acid ethyl ester 
• 59223-88-0 ethyl 2-acetamido-2-methoxy3-phenylpropanoate 

Relevant academic research and scientific papers

Synthetic method of monoamino inhibitor intermediate monoethyl 2-acetylamino-2-benzylmalonate

The invention discloses a synthetic method of a monoamino inhibitor intermediate monoethyl 2-acetylamino-2-benzylmalonate. The method comprises the following steps: 1, carrying out amino protection on a compound I diethyl aminomalonate and di-tert-butyl d

Towards a universal organocatalyst for the synthesis of enantioenriched phenylalanine derivatives by enantioselective decarboxylative protonation

Access to enantioenriched non-proteogenic phenylalanine derivatives is described using the enantioselective decarboxylative protonation reaction of amidohemimalonate esters catalysed by various cinchona-based compounds. This study compares the catalytic efficiency as well as the enantioselectivity induced by three types of common organocatalysts, namely thioureas, squaramides and bis-cinchona squaramides. One of the main outcome of this work is the observation of a significant influence of the N-protecting group of the hemimalonate on its interaction with the catalyst. This methodology carried out under mild conditions exhibits good substrate scope and functional group tolerance. A substoichiometric amount of catalyst can also be used in certain cases while affording good yields and selectivities.