59234-33-2

Upstream product

• 4916-29-4 dimethyl (Z)-N-(phenyl)aminofumarate 
• 123-11-5 4-methoxy-benzaldehyde 
• 62-53-3 aniline 
• 762-42-5 dimethyl acetylenedicarboxylate 

Relevant academic research and scientific papers

Visible-light-mediated synthesis of 3,4,5-trisubstituted furan-2-one derivatives: Via a bifunctional organo photocatalyst

Furan-2-one derivatives are of great importance in chemistry for both synthetic and biological purposes. Herein, we report a new approach towards their synthesis via a mild, inexpensive, and green photochemical protocol, where dual analyte thioureas, 1 (1

Sonosynthesis of furan-2(5H)-ones using nanosilica-tethered polyhedral oligomeric silsesquioxanes

Abstract: An easy and rapid method for the synthesis of 3,4,5-substituted furan-2 (5H)-ones has been achieved through a three-component reaction of aniline, dialkyl acetylenedicarboxylate, and aromatic aldehydes using nanosilica-tethered polyhedral oligom

Efficient One-Pot Three-Component Synthesis of 3,4,5-Substituted Furan-2(5 H)-ones Catalyzed Watermelon Juice

A simple, efficient, and environmentally benign protocol for the synthesis of 3,4,5-substituted furan-2(5H)-ones has been achieved using extract of watermelon as a natural catalyst. We found, for the first time, that the extract of watermelon could effectively catalyze The condensation reaction of aldehydes, amines, and dialkyl acetylenedicarboxylates to 3,4,5-substituted furan-2(5H)-ones in excellent yields under mild conditions. The low cost, easy availability of the catalyst, and simple reaction conditions suggest the possible use of the present method for large scale preparations.

ZnO nanoparticle-catalyzed efficient one-pot three-component synthesis of 3,4,5-trisubstituted furan-2(5H)-ones

An efficient and high-yielding protocol using nano-ZnO (50-100 nm) as an efficient heterogeneous catalyst for one-pot three-component synthesis of pharmacologically significant furanone derivatives by the condensation of aromatic aldehyde, amine and dimethylacetylenedicarboxylate has been developed. Since the catalyst is heterogeneous, it can be easily separated and recycled several times without much loss of its catalytic activity. Use of aqueous medium, recyclable nanocatalyst, operational simplicity, non-chromatographic purification technique, excellent yield and short reaction time makes this approach an attractive protocol for the synthesis of 3,4,5-trisubstituted furan-2(5H)-ones.

Acetic acid as an efficient catalyst for the one-pot preparation of 3,4,5-substituted furan-2(5H)-ones

The three-component condensation reaction of aldehydes, amines,and dialkyl acetylenedicarboxylates was conducted, leading to the production of 3,4,5-substituted furan-2(5H)-ones. This reaction is performed in the presence of acetic acid as a cheap and readily available catalyst at room temperature. Graphical Abstract: [Figure not available: see fulltext.]

An efficient one-pot multi-component synthesis of 3,4,5-substituted furan-2(5H)-ones catalyzed by tetra-n-butylammonium bisulfate

A facile one-pot synthesis of 3,4,5-substituted furan-2(5H)-one derivatives from a three-component reaction of aniline derivatives, dialkylacetylenedicarboxylates and aromatic aldehydes under mild conditions using tetra-n-butylammonium bisulfate as a catalyst has been developed.

Application of silica gel-supported polyphosphoric acid (PPA/SiO 2) as a reusable solid acid catalyst for one-pot multi-component synthesis of 3,4,5-substituted furan-2(5H)-ones

3,4,5-substituted furan-2(5H)-ones were One-Pot Multi-Component synthesized by the reaction of aldehydes, amines and dialkyl acetylenedicarboxylates using silica gel-supported polyphosphoric acid (PPA/SiO2) at room temperature. This reaction provides a convenient and efficient synthetic method of furan-2(5H)-one derivatives, and also reusability of catalyst.

Simple, convenient method for the synthesis of substituted furan-2(5 H)-one derivatives using tin(II) chloride

Furan-2(5H)-one derivatives have been synthesized by a simple, efficient, one-pot, three-component condensation of anilines, dimethylacetylenedicarboxylate, and aromatic aldehydes in the presence of a catalytic amount of tin(II) chloride in excellent yields.