59235-35-7

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 2-(4-aminophenyl)acetate is utilized as an intermediate in the synthesis of various drugs, particularly those with analgesic and anti-inflammatory properties. Its presence in the production process contributes to the development of medications that alleviate pain and reduce inflammation.
Used in Chemical Production:
ethyl 2-(4-aminophenyl)acetate is also employed in the production of pigments, dyes, and other organic compounds. Ethyl 2-(4-aminophenyl)acetate's role in these processes highlights its versatility and importance in creating a range of colorants and organic substances for different applications.
It is crucial to handle ethyl 2-(4-aminophenyl)acetate with care due to its potential hazards if not used properly, emphasizing the need for proper safety measures during its application in various industries.

Upstream product

• 64-17-5 ethanol 
• 1197-55-3 4-aminophenylacetic acid 
• 5445-26-1 ETHYL 4-NITROPHENYLACETATE 

Downstream Products

• 774602-80-1 {4-[2-(2-chloroethoxy)-acetylamino]-phenyl}-acetic acid ethyl ester 
• 169186-00-9 (RS)-2-(4-chlorobenzenesulfonylamino)-N-(4-(ethoxycarbonylmethyl)phenyl)-4-(tetrahydropyran-2-yloxy)butanamide 
• 169186-11-2 (RS)-2-(4-chlorobenzenesulfonylamino)-N-(4-(ethoxycarbonylmethyl)phenyl)hexanamide 

Relevant academic research and scientific papers

Organosilicon synthesis of isocyanates: III. Synthesis of aliphatic, carbocyclic, aromatic, and alkylaromatic isocyanatocatboxylic acid esters

A series of aminoacid esters was prepared by treating the aminoacid suspensions in ethanol with thionyl chloride. Best conversion of aminoacid esters to corresponding isocyanates was achieved in the case of aromatic and carbocyclic aminoesters by phosgeneation of their N-silyl derivatives, and in the case of aliphatic and alkylaromatic aminoesters by phosgeneation of O-silyl or N,O-bissilylurethanes on their basis. In the last case additional step of esterification of the by-products isocyanatoalkylcarboxylic acid chlorides is required after phosgeneation. Unusual generation of cynnamates and intramolecular N→O-migration of trimethylsilyl group in the solutions of silylated alkylaromatic β-aminoacid esters were found. Pleiades Publishing, Inc., 2006.

Synthesis and Serotonergic Activity of 5-(Oxadiazolyl)tryptamines: Potent Agonists for 5-HT1D Receptors

The synthesis and 5-HT1D receptor activity of a novel series of 5-(oxadiazolyl)tryptamines is described.Modifications of the oxadiazole 3-substituent, length of the linking chain (n), and the amine substituents are explored and reveal a large binding pocket in the 5-HT1D receptor domain.Oxadiazole substituents such as benzyl are accommodated without loss of agonist potency or efficacy.The incorporation of polar functionality on a phenyl or benzyl spacer group results in a 10-fold increase in affinity and functional potency.Optimal 5-HT1D activity is observed when the heterocycle is conjugated with the indole and the benzyl sulfonamides 20t and 20u represent some of the most potent 5-HT1D agonist known.Replacement of O for S in the heterocycle leads to a further increase in potency.Deletion of oxadiazole N-2 does not reduce activity, suggesting the requirements for only one H-bond acceptor in this location.The selectivity of these compounds for 5-HT1D receptors over other serotonergic receptors is discussed.Sulfonamide 20t shows 1000-fold selectivity for 5-HT1D over 5-HT2, 5-HT1C, and 5-HT3 receptors and 10-fold selectivity with respect to 5-HT1A receptors.The functional activity of this series of compounds is studied and demonstrates high 5-HT1D receptor potency and efficacy comparable to that of 5-HT.