59236-36-1

Basic information

• Product Name: 2-amino-4-methoxy-benzaldehyde
• Synonyms: 2-amino-4-methoxy-benzaldehyde;4-Methoxy-2-aminobenzaldehyde;NSC 284153
• CAS NO: 59236-36-1
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.17
• Mol File: 59236-36-1.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 321.5°C at 760 mmHg
• Flash Point: 185.1°C
• Appearance: /
• Density: 1.186g/cm³
• Vapor Pressure: 0.000296mmHg at 25°C
• Refractive Index: 1.605
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -0.07±0.10(Predicted)
• CAS DataBase Reference: 2-amino-4-methoxy-benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-4-methoxy-benzaldehyde(59236-36-1)
• EPA Substance Registry System: 2-amino-4-methoxy-benzaldehyde(59236-36-1)

Safety Data

• Hazardous Substances Data: 59236-36-1(Hazardous Substances Data)

Usage

General Description

2-Amino-4-methoxy-benzaldehyde is a chemical compound with the molecular formula C9H9NO2. It is an organic compound with a benzene ring substituted with an amino group and a methoxy group, as well as an aldehyde functional group. 2-amino-4-methoxy-benzaldehyde is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It has also been studied for its potential biological activities, including its anticancer and antimicrobial properties. Additionally, it is used in the production of dyes and pigments due to its aromatic nature and the potential for coloration. Overall, 2-amino-4-methoxy-benzaldehyde plays a crucial role in the field of organic chemistry and has various applications in different industries.

InChI:InChI=1/C8H9NO2/c1-11-7-3-2-6(5-10)8(9)4-7/h2-5H,9H2,1H3

Upstream product

• 187731-65-3 (2-amino-4-methoxyphenyl)methanol 
• 4294-95-5 4-methoxyanthranilic acid 
• 5344-90-1 2-Aminobenzyl alcohol 
• 17484-36-5 4-Methyl-3-nitroanisole 
• 1335101-95-5 1-(E)-(2-(4-methoxy-2-nitrophenyl)vinyl)pyrrolidine 
• 22996-21-0 4-methoxy-2-nitro-benzaldehyde 

Downstream Products

• 91099-24-0 2-hydroxy-7-methoxyquinazoline 
• 1395473-93-4 (S)-7-methoxy-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroquinoline 
• 852402-71-2 7-methoxyquinoline-2-carboxylic acid 
• 462066-82-6 7-methoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid 
• 953039-95-7 2-(4-(morpholine-4-sulfonyl)phenylamino)-quinazolin-7-yl trifluoromethanesulfonate 
• 953039-15-1 2-chloro-7-methoxyquinazoline 

Relevant articles and documents

Cationic Iridium-Catalyzed Asymmetric Decarbonylative Aryl Addition of Aromatic Aldehydes to Bicyclic Alkenes

We report an unprecedented catalytic protocol for the enantioselective decarbonylative transformation of aryl aldehydes. In this process, the decarbonylation of aldehydes catalyzed by chiral iridium complexes enabled the formation of asymmetric C?C bonds

Identification of Inhibitors of Cholesterol Transport Proteins Through the Synthesis of a Diverse, Sterol-Inspired Compound Collection

Cholesterol transport proteins regulate a vast array of cellular processes including lipid metabolism, vesicular and non-vesicular trafficking, organelle contact sites, and autophagy. Despite their undoubted importance, the identification of selective modulators of this class of proteins has been challenging due to the structural similarities in the cholesterol-binding site. Herein we report a general strategy for the identification of selective inhibitors of cholesterol transport proteins via the synthesis of a diverse sterol-inspired compound collection. Fusion of a primary sterol fragment to an array of secondary privileged scaffolds led to the identification of potent and selective inhibitors of the cholesterol transport protein Aster-C, which displayed a surprising preference for the unnatural-sterol AB-ring stereochemistry and new inhibitors of Aster-A. We propose that this strategy can and should be applied to any therapeutically relevant sterol-binding protein.

Synthesis of 3-acylindoles by oxidative rearrangement of 2-aminochalcones using a hypervalent iodine reagent and cyclization sequence

An efficient one-pot method was developed for the construction of 3-acylindoles via oxidative rearrangement of 2-aminochalcones followed by intramolecular cyclization. The reaction was used to convert a variety of 2-aminochalcones into 3-acylindoles in mo