22996-21-0

Basic information

• Product Name: 4-METHOXY-2-NITRO-BENZALDEHYDE
• Synonyms: 4-METHOXY-2-NITRO-BENZALDEHYDE;4-Formyl-3-nitroanisole, 2-Formyl-5-methoxynitrobenzene;Benzaldehyde, 4-methoxy-2-nitro-;4-Mehtyl-2-Nitro-Benzaldehyde
• CAS NO: 22996-21-0
• Molecular Formula: C₈H₇NO₄
• Molecular Weight: 181.15
• Product Categories: Aldehydes;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 22996-21-0.mol
• Article Data: 15

Chemical Properties

• Melting Point: 95.5-96 °C(Solv: chloroform (67-66-3); ligroine (8032-32-4))
• Boiling Point: 354.7 °C at 760 mmHg
• Flash Point: 184.2 °C
• Appearance: /
• Density: 1.322 g/cm³
• Vapor Pressure: 3.28E-05mmHg at 25°C
• Refractive Index: 1.59
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-METHOXY-2-NITRO-BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXY-2-NITRO-BENZALDEHYDE(22996-21-0)
• EPA Substance Registry System: 4-METHOXY-2-NITRO-BENZALDEHYDE(22996-21-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 22996-21-0(Hazardous Substances Data)

Usage

General Description

4-METHOXY-2-NITRO-BENZALDEHYDE is a chemical compound with the molecular formula C8H7NO4. It is a yellow crystalline solid that is commonly used as an intermediate in the synthesis of various pharmaceuticals, dyes, and perfumes. 4-METHOXY-2-NITRO-BENZALDEHYDE is also known for its potential use as a reagent in organic chemical reactions. However, it is important to note that 4-METHOXY-2-NITRO-BENZALDEHYDE should be handled with care as it is considered to be a hazardous chemical, and proper safety precautions should be taken when working with it.

InChI:InChI=1/C8H7NO4/c1-13-7-3-2-6(5-10)8(4-7)9(11)12/h2-5H,1H3

Upstream product

• 57559-52-1 4-methoxy-2-nitrobenzyl bromide 
• 17484-36-5 4-Methyl-3-nitroanisole 
• 75-15-0 carbon disulfide 
• 75-17-2 formaldoxime 
• 96-96-8 4-methoxy-2-nitroaniline 
• 38469-83-9 4-methoxy-2-nitro-benzonitrile 
• 5344-78-5 4-bromo-3-nitroanizole 
• 123-11-5 4-methoxy-benzaldehyde 
• 1335101-95-5 1-(E)-(2-(4-methoxy-2-nitrophenyl)vinyl)pyrrolidine 
• 119-32-4 4-Methyl-3-nitroanilin 
• 2042-14-0 4-methyl-5-nitrophenol 
• 33844-21-2 2-nitro-4-methoxybenzoic acid 
• 22996-23-2 (4-methoxy-2-nitro-phenyl)-methanol 
• 100193-41-7 2-Nitro-4-methoxy-benzaldiacetat 

Downstream Products

• 109300-72-3 2-(4-Methoxy-2-nitro-benzylidene)-malonic acid 
• 88932-49-4 1-(2-Nitro-4-methoxyphenyl)-3-(trimethylsilyl)-prop-1-ene 
• 55149-63-8 (E)-2-Cyano-3-(4-methoxy-2-nitro-phenyl)-acrylamide 
• 99459-34-4 2,β-Dinitro-4-methoxy-styrol 
• 4176-34-5 α-(4,5-Dimethoxy-phenyl)-4-methoxy-2-nitro-zimtsaeure 
• 130862-01-0 2-(6-bromo-benzo[1,3]dioxol-5-yl)-3t-(4-methoxy-2-nitro-phenyl)-acrylic acid 
• 111586-54-0 4'-methoxy-3,4-methylenedioxy-2'-nitro-cis-stilbene-α-carboxylic acid 
• 1027298-73-2 (4-methoxy-2-nitrophenyl)(3,4,5-trimethoxyphenyl)methanol 
• 908583-89-1 (Z)-3-(4-methoxy-2-nitrophenyl)-2-(4-methoxyphenyl)acrylonitrile 
• 942614-32-6 2-(4-methoxy-2-nitrophenyl)-1H-benzo[d]imidazole 
• 531-59-9 7-methoxycoumarin 
• 33844-21-2 2-nitro-4-methoxybenzoic acid 
• 141080-74-2 2-[⁽¹⁸⁾F]-fluoro-4-methoxybenzaldehyde 
• 519060-36-7 4-methoxy-2,3-dinitrobenzaldehyde 

Relevant articles and documents

ARYLOXYACETYLINDOLES AND ANALOGS AS ANTIBIOTIC TOLERANCE INHIBITORS

The disclosure provides compounds and pharmaceutical compositions of aryloxyacetylindoles compounds and analogs useful for treating chronic and acute bacterial infections. Certain of the compounds are compounds of general Formula (I) (I) or a pharmaceutically acceptable salt or prodrug thereof. Certain compounds of this disclosure are MvfR inhibitors. MvfR inhibitors reduce the formation of antibiotic tolerant bacterial strains and are useful for treating Gram-negative bacterial infections and reducing the virulence of Pseudomonas aeruginosa. Methods of treating bacterial infections in a subject, including Pseudomonas aeruginosa infections, are also provided by the disclosure.

Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors

Abstract Protein-protein interactions are critical for regulating the activity of translation initiation factors and multitude of other cellular process, and form the largest block of untapped albeit most challenging targets for drug development. 4EGI-1, (E/Z)-2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl) hydrazono)-3-(2-nitrophenyl)propanoic acid, is a hit compound discovered in a screening campaign of small molecule libraries as an inhibitor of translation initiation factors eIF4E and eIF4G protein-protein interaction; it inhibits translation initiation in vitro and in vivo. A series of 4EGI-1-derived thiazol-2-yl hydrazones have been designed and synthesized in order to delineate the structural latitude and improve its binding affinity to eIF4E, and increase its potency in inhibiting the eIF4E/eIF4G interaction. Probing a wide range of substituents on both phenyl rings comprising the 3-phenylpropionic acid and 4-phenylthiazolidine moieties in the context of both E- and Z-isomers of 4EGI-1 led to analogs with enhanced binding affinity and translation initiation inhibitory activities.

Ethylammonium nitrate (EAN)/Tf2O and EAN/TFAA: Ionic liquid based systems for aromatic nitration

Acting as in situ sources of triflyl nitrate (TfONO2) and trifluoroacetyl nitrate (CF3COONO2), the EAN/Tf 2O and EAN/TFAA systems, generated via metathesis in the readily available ethylammonium nitrate (EAN) ionic liquid as solvent, are powerful electrophilic nitrating reagents for a wide variety of aromatic and heteroaromatic compounds. Comparative nitration experiments indicate that EAN/Tf2O is superior to EAN/TFAA for nitration of strongly deactivated systems. Both systems exhibit low substrate selectivity (K T/KB = 5-10) in (Figure presented) between values reported for covalent nitrates and preformed nitronium salts.