95273-61-3

Upstream product

• 111-71-7 heptanal 
• 21964-44-3 non-1-en-3-ol 
• 59262-86-1 3-(6-Amino-purin-9-yl)-nonan-2-ol 
• 79854-87-8 (2R,3RS)-3-Amino-2-nonanol 
• 95209-65-7 Benzoic acid (1R,2R)-2-azido-1-methyl-octyl ester 
• 95209-64-6 Benzoic acid (1R,2S)-2-hydroxy-1-methyl-octyl ester 
• 95209-62-4 2-((S)-(R)-1-Oxiranyl-heptyloxy)-tetrahydro-pyran 
• 95209-63-5 (2R,3S)-3-(Tetrahydro-pyran-2-yloxy)-nonan-2-ol 
• 79605-69-9 1,2R-epoxy-nonane-3S-ol 
• 5413-85-4 5-amino-4,6-dichloropyridimine 
• 79854-85-6 2S-hydroxy-3R-nonylamine 
• 122-51-0 orthoformic acid triethyl ester 
• 95209-66-8 N-[(R)-1-((R)-1-Hydroxy-ethyl)-heptyl]-benzamide 
• 95209-68-0 (S)-2-((R)-1-Azido-heptyl)-oxirane 

Relevant academic research and scientific papers

ENANTIOSPECIFIC SYNTHESIS OF THE IMMUNOPOTENTIATORS erythro-9 (2-HYDROXY-3-NONYL) HYPOXANTHINES AND THE threo-DIASTEREOMERS.

The title compounds were prepared enantiospecifically by kinetic resolution of (+/-) 1-nonene-3-ol via Sharpless oxidation.The products 1,2R-epoxy-nonane-3S-ol and 1-nonene-3R-ol were efficiently converted to all four stereoisomers of 2-hydroxy-3-nonylamine, which were subsequently incorporated into the target hypoxanthines to evaluate their immunopotentiating activity.

Method of imparting immunomodulating and antiviral activity

Compounds of the formula STR1 where X is OH, NH2, SH, OR or SR (where R is alkyl of 1 to 4 carbon atoms or benzyl), R1 is H or alkyl of 1 to 8 carbon atoms, R2 is H or methyl, Y is the salt of an amine of the formula STR2 where R3 and R4 are lower alkyl, e.g., 1 to 4 carbon atoms and n is an integer of 2 to 4 with p-acetamidobenzoic acid and where z is a number from 0 to 10 are useful as immunomodulators, as antiviral agents and in specific cases have anti-leukemic activity. The compounds and compositions where z is 1 to 10 are novel per se. When R2 is H the presence of Y enhances the immunoregulatory activity and the antiviral activity. If X is the NH2 there is immunoinhibitory activity but no immunostimulatory (immunopotentiatory) activity.

9-(Hydroxy alkyl)purines

There are prepared compounds of the formula STR1 where X is OH, R2 is CH3 and R1 is alkyl of 1 to 8 carbon atoms. The compounds are immunopotentiators, have antiviral activity and anti-leukemic activity.