59265-81-5

Basic information

• Product Name: 4-amino-2-chloro-benzoic acid isopropyl ester
• CAS NO: 59265-81-5
• Molecular Weight: 213.664
• Mol File: 59265-81-5.mol

Chemical Properties

• CAS DataBase Reference: 4-amino-2-chloro-benzoic acid isopropyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-2-chloro-benzoic acid isopropyl ester(59265-81-5)
• EPA Substance Registry System: 4-amino-2-chloro-benzoic acid isopropyl ester(59265-81-5)

Safety Data

• Hazardous Substances Data: 59265-81-5(Hazardous Substances Data)

Upstream product

• 7073-36-1 2-chloro-4-nitrobenzoyl chloride 
• 59265-73-5 2-Chloro-4-nitro-benzoic acid isopropyl ester 
• 2457-76-3 4-amino-2-chlorobenzoic acid 
• 67-63-0 isopropyl alcohol 

Downstream Products

• 58055-33-7 2-Chloro-4-(3,3-dimethyl-ureido)-benzoic acid isopropyl ester 
• 241127-80-0 NSC 686561 
• 59265-90-6 2-Chloro-4-isocyanato-benzoic acid isopropyl ester 

Relevant articles and documents

Synthesis, structure-activity relationship, and p210bcr-abl protein tyrosine kinase activity of novel AG 957 analogs

A series of novel, sterically hindered lipophilic analogs of AG 957 was designed and synthesized as potential protein tyrosine kinase (PTK) inhibitors. The in vitro activity, in vivo anti-leukemia activity, and pharmacology of these PTK inhibitors were studied. Some aspects of the structure-activity relationship associated with the carboxylic acid, phenol ring, and linker modifications are discussed. We have demonstrated that the 1,4-hydroquinone moiety is essential for activity and that sterically hindered esters contribute to enhanced in vivo efficacy. Adaphostin (NSC 680410) has emerged as the improved compound with the maximum in vivo anti-leukemia hollow fiber activity, concordant with the original lead compound AG 957. Currently, adaphostin is undergoing preclinical toxicology studies.