59278-01-2Relevant academic research and scientific papers
Real-time measurements of protein dynamics using fluorescence activation-coupled protein labeling method
Komatsu, Toru,Johnsson, Kai,Okuno, Hiroyuki,Bito, Haruhiko,Inoue, Takanari,Nagano, Tetsuo,Urano, Yasuteru
, p. 6745 - 6751 (2011/06/22)
We present a fluorescence activation-coupled protein labeling (FAPL) method, which employs small-molecular probes that exhibit almost no basal fluorescence but acquire strong fluorescence upon covalent binding to tag-proteins. This method enables real-time imaging of protein labeling without any washout process and is uniquely suitable for real-time imaging of protein dynamics on the cell surface. We applied this method to address the spatiotemporal dynamics of the EGF receptor during cell migration.
2-Amido-9-(2-acyloxyethoxymethyl)hypoxanthines
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, (2008/06/13)
Method of preparing 9-(2-hydroxyethoxymethyl)guanine which comprises preparing the compound STR1 wherein R and R1 are hydrogen, lower alkyl and phenyl and then hydrolyzing same. 9-(2-hydroxyethoxymethyl)guanine is useful as an antiviral.
