59283-35-1

Usage

Uses

Used in Pharmaceutical Industry:
(1-benzyl-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid is used as a potential pharmaceutical agent for its possible receptor-binding capabilities, which could be harnessed for the development of new drugs targeting specific biological pathways.
Used in Chemical Research:
In the field of chemical research, (1-benzyl-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid serves as a subject for studying the effects of its complex structure on biological systems, potentially leading to insights into drug design and the discovery of novel therapeutic agents.

Upstream product

• 624-45-3 levulinic acid methyl ester 
• 5705-10-2 N-benzyl-N-(4-methoxy-phenyl)-hydrazine; hydrochloride 
• 2882-15-7 5-Methoxy-2-methylindole-3-acetic acid 
• 100-44-7 benzyl chloride 
• 3471-32-7 4-Methoxyphenylhydrazine 
• 163734-87-0 (1-Benzyl-5-methoxy-2-methyl-1H-indol-3-yl)-acetic acid benzyl ester 

Downstream Products

• 57846-28-3 (1-benzyl-5-methoxy-2-methyl-indol-3-yl)-acetic acid methyl ester 
• 163735-06-6 2-(1-benzyl-5-hydroxy-2-methyl-1H-indol-3-yl)acetic acid 
• 909390-30-3 ethyl 2-(2-(1-benzyl-5-methoxy-2-methyl-1H-indol-3-yl)acetamido)acetate 
• 172595-31-2 8-[[5-Methoxy-1-benzyl-2-methyl-1H-indol-3-yl]-acetylamino]-octanoic acid methyl-butyl-amide 
• 441-91-8 2-(1-benzyl-5-methoxy-2-methyl-indol-3-yl)-ethylamine 
• 185501-86-4 4-(1-Benzyl-3-methoxycarbonylmethyl-2-methyl-1H-indol-5-yloxy)-butyric acid ethyl ester 
• 164084-38-2 2-[[3-(2-amino-2-oxoethyl)-2-methyl-1-(phenylmethyl)-1H-indol-5-yl]oxy]acetic acid ethyl ester 
• 164083-73-2 5-(carbethoxymethoxy)-2-methyl-1-(phenylmethyl)-1H-indole-3-acetic acid 
• 163735-05-5 5-hydroxy-2-methyl-1-(phenylmethyl)-1H-indole-3-acetic acid methyl ester 
• 110147-46-1 (1-benzyl-5-methoxy-2-methyl-indol-3-yl)-acetic acid dimethylamide 
• 14075-46-8 [2-(1-benzyl-5-methoxy-2-methyl-indol-3-yl)-ethyl]-dimethyl-amine 
• 97077-43-5 3-(amidomethyl)-2-methyl-1-(phenylmethyl)-5-methoxyindole 

Relevant academic research and scientific papers

Synthesis of amino acid derivatives of indole-3-acetic acid

Amino acid derivatives of a modified indole-3-acetic acid have been synthesised. Fourteen new dipeptide-like compounds 3-4 were obtained and their structures were elucidated based on the IR, 1H NMR, MS spectra.

Synthesis of indomethacin analogues for evaluation as modulators of MRP activity

Synthesis of a range of indomethacin analogues, required for investigation in combination toxicity assays, bearing both N-benzyl and N-benzoyl groups, is described. Copyright

1H-INDOLE-3-ACETAMIDE SPLA2 INHIBITORS

A class of novel 1-indole-3-acetamides represented by the formula; is disclosed together with the use of such indole compounds for inhibiting sPLA2 mediated release of fatty acids.

Indole inhibitors of human nonpancreatic secretory phospholipase A2. 1. Indole-3-acetamides

Phospholipases (PLAs) produce rate-limiting precursors in the biosynthesis of various types of biologically active lipids involved in inflammatory processes. Increased levels of human nonpancreatic secretory phospholipase A2 (hnps-PLA2) have been detected in several pathological conditions. An inhibitor of this enzyme could have therapeutic utility. A broad screening program was carried out to identify chemical structures which could inhibit hnps-PLA2. One of the lead compounds generated by the screening program was 5-methoxy-2-methyl-1-(phenylmethyl)-1H-indole-3-acetic acid (13a). We describe the syntheses, structure-activity relationships, and pharmacological activities of a series of indole-3-acetamides and related compounds derived from this lead. This SAR was undertaken with the aid of X- ray crystal structures of complexes between the inhibitors and hnps-PLA2 which were of great value in directing the SAR.

1H-INDOLE-3-ACETIC ACID HYDRAZIDE SPLA2 INHIBITORS

A class of novel 1H-indole-3-acetic acid hydrazides is disclosed together with the use of such indole compounds for inhibiting sPLA2 mediated release of fatty acids (e.g., arachidonic acid) for treatment of conditions such as septic shock