59303-17-2Relevant articles and documents
CYCLIC SULFAMIDE COMPOUNDS AND METHODS OF USING SAME
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Page/Page column 238, (2018/09/21)
The present disclosure provides, in part, cyclic sulfamide compounds, and pharmaceutical compositions thereof, useful as modulators of Hepatitis B (HBV) core protein, and methods of treating Hepatitis B (HBV) infection.
DIHYDROPYRIDINONE MGAT2 INHIBITORS FOR USE IN THE TREATMENT OF METABOLIC DISORDERS
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Page/Page column 57, (2015/11/02)
The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.
Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)
Farmer, Luc J.,Bemis, Guy,Britt, Shawn D.,Cochran, John,Connors, Martin,Harrington, Edmund M.,Hoock, Thomas,Markland, William,Nanthakumar, Suganthini,Taslimi, Paul,Haar, Ernst Ter,Wang, Jian,Zhaveri, Darshana,Salituro, Francesco G.
scheme or table, p. 6231 - 6235 (2009/08/07)
A series of SYK inhibitors based on the phenylamino pyrimidine thiazole lead 4 were prepared and evaluated for biological activity. Lead optimization provided compounds with nanomolar Ki's against SYK and potent inhibition in mast cell degranulation assays.