3581-89-3Relevant articles and documents
Volatile Compounds from the Reaction of Cysteine, Ribose, and Phospholipid in Low-Moisture Systems
Mottram, Donald S.,Whitfield, Frank B.
, p. 984 - 988 (1995)
The headspace volatiles from Maillard reaction mixtures of cysteine and ribose heated at 185 deg C with or without the addition of phosphatidylcholine, either dry or in the presence of a small quantity of water, were analyzed by GC-MS.The major products of the reaction were 3,5-dimethyl-1,2,4-trithiolane, 3-methyl-1,2,4-trithiane, 3,6-dimethyl-1,2,4,5-tetrathiane, and thienothiophene.Other products included a number of thiazoles and small amounts of some furanthiols and disulfides.Water had a significant effect on the relative amounts of volatiles produced; in particular, 1-(2-furanylmethyl)-1H-pyrrole, two other 1-(2-furanylmethyl)alkyl-1H-pyrroles, and two bis(furan) compounds were only produced to any extent in systems without water.The addition of lipid had only a small effect on the volatile profile, with small amounts of lipid degradation products and lipid/Maillard interaction products formed.These results differ greatly from previous studies on the volatiles formed in reaction systems carried out in the presence of large quantities of water.Keywords: Volatiles; Maillard reaction; moisture content; phospholipid
THE MICROWAVE SPECTRUM OF 5-METHYLTHIAZOLE: METHYL INTERNAL ROTATION, 14N NUCLEAR QUADRUPOLE COUPLING AND ELECTRIC DIPOLE MOMENT
Jaeger, W.,Maeder, H.
, p. 295 - 306 (1988)
The microwave spectrum of 5-methylthiazole has been investigated in the frequency range from 8 to 36 GHz, employing both Fourier transform and Stark spectroscopy.Double resonance MWFT techniques with broadband pump excitation were applied in order to facilitate the assignment of the spectrum.The results of methyl internal rotation, 14N quadrupole hyperfine structure and fourth order centrifugal distortion analyses are given.The dipole moment components, with respect to the principal inertia axes system, could be determined from the Stark splittings of selected rotational lines.
Rearrangement reactions; 14: Synthesis of functionalized thiazoles via attack of heteroatom nucleophiles on allenyl isothiocyanates
Banert, Klaus,Al-Hourani, Baker Jawabrah,Groth, Stefan,Vrobel, Kai
, p. 2920 - 2926 (2007/10/03)
Treatment of allenyl isothiocyanates with sulfur-, oxygen-, nitrogen- or hydride-containing nucleophiles such as propane-2-thiol, thiophenol, hydrogen sulfide, alcohols, phenol or aqueous NaOH, NH3, primary or secondary aliphatic or aromatic amines, N,N,N′,N′-tetramethylguanidine or sodium cyanoborohydride resulted in ring closure to generate thiazoles bearing a functionality at position C-2 in most cases. Moreover, we report the first examples of aromatic miazole-2-phosphonates prepared by the same strategy using dialkyl or diphenyl phosphites as nucleophiles. Georg Thieme Verlag Stuttgart.
Method for treating glaucoma IIB
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, (2008/06/13)
Provided is a method of decreasing intraocular pressure or improving ocular accommodation in an animal, including a human, comprising administering an intraocular pressure decreasing amount or ocular accommodation improving amount of a compound of the formula I or IA, wherein J is oxygen, sulfur, or N—Rd.