59304-99-3

Basic information

• Product Name: 2-hydroxy-3-(4-methoxybenzyl)naphthalene-1,4-dione
• Synonyms: 2-hydroxy-3-(4-methoxybenzyl)naphthalene-1,4-dione
• CAS NO: 59304-99-3
• Molecular Weight: 294.307
• Mol File: 59304-99-3.mol

Chemical Properties

• CAS DataBase Reference: 2-hydroxy-3-(4-methoxybenzyl)naphthalene-1,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-3-(4-methoxybenzyl)naphthalene-1,4-dione(59304-99-3)
• EPA Substance Registry System: 2-hydroxy-3-(4-methoxybenzyl)naphthalene-1,4-dione(59304-99-3)

Safety Data

• Hazardous Substances Data: 59304-99-3(Hazardous Substances Data)

Upstream product

• 27699-93-0 2‐hydroxy‐1,4‐naphthoquinone 
• 123-11-5 4-methoxy-benzaldehyde 
• 83-72-7 2-hydroxynaphtho-1,4-quinone 
• 104-93-8 p-methylanizole 

Downstream Products

• 54808-10-5 3-(4'-Acetoxyphenyl)-naphthalin-1,2,4-triyl-triacetat 
• 54808-09-2 Acetic acid 1,4-diacetoxy-3-(4-methoxy-phenyl)-naphthalen-2-yl ester 
• 54808-21-8 1,4-dihydro-2-hydroxy-3-(4-methoxyphenyl)-1,4-naphthalenedione 

Relevant articles and documents

Organocatalytic Enantioselective Michael-Aldol[3+2] Annulation for the Synthesis of Nitro-Methanobenzo[7] annulenes

We report an enantioselective Michael-Aldol[3+2] annulation between 2-alkyl-3-hydroxynaphthalene-1,4-diones and nitroalkenes using a bifunctional thiourea catalyst, and a series of nitro-methanobenzo[7]annulenes with potential biological activities were synthesized in good yields with excellent enantio- and diastereoselectivities. A gram-scale synthesis and further transformation of the product demonstrated the synthetic value of this reaction.

Organocatalytic Asymmetric Formal [3+2] Cycloaddition as a Versatile Platform to Access Methanobenzo[7]annulenes

Pharmaceutically and structurally important methanobenzo[7]annulenes were synthesized in very good yields with excellent enantio- and diastereoselectivities through an unprecedented organocatalytic formal [3+2] cycloaddition from readily available 2-alkyl-3-hydroxynaphthalene-1,4-diones and alkyl vinyl ketones.

A new method to prepare 3-alkyl-2-hydroxy-1,4-naphthoquinones: Synthesis of lapachol and phthiocol

In this article a mild, simple, safe, and chemoselective synthesis and reduction of o-quinone methides to the corresponding 3-alkyl-2-hydroxy-1,4- naphthoquinones, compounds with interesting biological activity, mediated by the formic acid-water system is described. This new one-pot methodology was applied to the synthesis of lapachol and constitutes an efficient and inexpensive alternative for the preparation of this natural bioactive compound Georg Thieme Verlag Stuttgart ? New York.