59315-46-7

Usage

Uses

Used in Pharmaceutical Industry:
5-Amino-2-hydroxypyridine is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs.
Used in Pesticide Industry:
In the pesticide industry, 5-Amino-2-hydroxypyridine is used as an intermediate in the production of various pesticides, highlighting its role in agricultural chemistry.
Used in Dye Industry:
5-Amino-2-hydroxypyridine is used as a colorant in the dye industry, particularly for its ability to impart specific shades to different materials.
Used in Hair Dye Production:
In the hair dye production, 5-Amino-2-hydroxypyridine is used as a colorant to provide specific shades to hair, enhancing its appearance and coloration properties.
Used in Medicinal Chemistry Research:
5-Amino-2-hydroxypyridine is used in medicinal chemistry research for its potential therapeutic properties, including antioxidant and metal chelating activities, making it a compound of interest for further study and development.
It is important to handle 5-Amino-2-hydroxypyridine with care due to its potential to cause irritation to the skin, eyes, and respiratory tract upon exposure.

InChI:InChI=1/C5H8N2/c6-5-2-1-3-7-4-5/h1-2,4,7H,3,6H2

Upstream product

• 33630-94-3 5-amino-2-hydroxypyridine 
• 24242-20-4 5-amino-pyridine-2-carboxylic acid 

Relevant academic research and scientific papers

Transformation of Streptonigrin to Streptonigrone: Flavin Reductase-Mediated Flavin-Catalyzed Concomitant Oxidative Decarboxylation of Picolinic Acid Derivatives

In the flavin-reductase-catalyzed reducing condition, a mild and efficient α-hydroxylation and decarboxylation procedure using natural flavins as a catalyst and atmospheric oxygen as an external oxidizing agent has been successfully developed and applied

SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS

Pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.

Chroman derivative and pharmaceutical use thereof

Chroman derivatives of the formula ?I! STR1 wherein R1 is a cyano, a nitro, a trihalomethyl, a trihalomethoxy or a halogen atom; R2 is a lower alkoxyalkyl, an aryloxyalkyl or a dialkoxyalkyl; R3 is a lower alkoxyalkyl or an aryloxyalkyl; R4 is a hydroxy, a formyloxy or a lower alkanoyloxy; X is N--H, an N--optionally substituted lower alkyl, an oxygen atom, a sulfur atom or a single bond; and Y is an optionally substituted aromatic ring residue or an optionally substituted heterocyclic residue, pharmaceutically acceptable salts thereof and pharmaceutical use thereof. The compound of the present invention and pharmaceutically acceptable salts thereof have selective and excellent coronary vasodilating action and extremely weak hypotensive action. Accordingly, it is possible to selectively increase the coronary blood flow without causing a sudden hypotention causative of tachycardia which has a detrimental effect on the heart, and they are useful as a coronary vasodilator, in particular, an agent for the prophylaxis and treatment of cardiovascular disorders such as angina pectoris and heart failure.

The Lactam-Lactim Tautomerization of Monoamino-Substituted 2-Pyridinols in Tetrahydrofuran

MINDO/3 calculations have been performed on 3-amino-, 4-amino-, 5-amino-, and 6-amino-2-pyridinols to estimate their molecular geometries.The lactam-lactim tautomerization from amino-2-pyridone to amino-2-pyridinol was expected for 5-amino- and 6-amino-2-pyridinols from the MINDO/3 calculations.In addition, their dimer formation energies were evaluated by the CNDO/2 method.Among the four amino-2-pyridones, 6-amino-2-pyridone has the largest dimer formation energy and 3-amino-2-pyridone the smallest.Furthermore, to certify the tautomerization of 3-amino-, 5-amino-, and 6-amino-2-pyridinols the UV absorption and fluorescence spectra were measured, and compared with those of their O-methyl and nuclear N-methyl derivatives.From the UV spectral data the equilibrium constants of the lactam-lactim tautomerization were determined for 5-amino and 6-amino derivatives in tetrahydrofuran (THF) at various temperatures.The lactam form is more stable than that of the lactim; the enthalpy changes between two forms of 5-amino and 6-amino derivatives were estimated to be 7.9 and 6.3 kJ mol-1, respectively.The lactam and lactim dimers of these two derivatives were found to be easily formed in THF and ether.From the fluorescence spectral data the lactim dimer of 6-amino derivative was found to be formed in the lowest excited ?,?* singlet state.On the other hand, the 3-amino derivative exists predominantly in the lactam monomer form in both the ground and the lowest excited ?,?* singlet states.