33630-94-3

Basic information

• Product Name: 3-Amino-6-hydroxypyridine
• Synonyms: 5-AMINO-PYRIDIN-2-OL;5-AMINO-2-PYRIDINOL;2-HYDROXY-5-AMINOPYRIDINE;2-Hydro-5-Amino-Pyridine;5-Amino-2-hydroxy prydine;5-AMINO-2-HYDROXPYRIDINE;5-AMINO-2-HYDROXYPYRIDINE/5-AMINO-2-PYRIDINOL;5-Amino-2-hydroxypyridine
• CAS NO: 33630-94-3
• Molecular Formula: C₅H₆N₂O
• Molecular Weight: 110.11
• EINECS: -0
• Product Categories: Nitrogen cyclic compounds;Pyridine Series;pharmacetical;Amines;Pyridines;Pyridine;Heterocyclic Compounds
• Mol File: 33630-94-3.mol
• Article Data: 13

Chemical Properties

• Melting Point: ca 180℃
• Boiling Point: 206.4°C (rough estimate)
• Flash Point: 141.7 °C
• Appearance: /
• Density: 1.208
• Vapor Pressure: 0.187mmHg at 25°C
• Refractive Index: 1.4800 (estimate)
• Storage Temp.: Refrigerated.
• PKA: 12.87±0.10(Predicted)
• CAS DataBase Reference: 3-Amino-6-hydroxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-6-hydroxypyridine(33630-94-3)
• EPA Substance Registry System: 3-Amino-6-hydroxypyridine(33630-94-3)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-40-22-36
• Safety Statements: 22-26-36
• Hazardous Substances Data: 33630-94-3(Hazardous Substances Data)

Usage

General Description

3-Amino-6-hydroxypyridine is a chemical compound with the molecular formula C5H6N2O. It is a derivative of pyridine, and its structure consists of a pyridine ring with an amino group at the 3-position and a hydroxy group at the 6-position. 3-Amino-6-hydroxypyridine is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used in the production of dyes and pigments. 3-Amino-6-hydroxypyridine has been identified as a potential mutagen and is considered to have low acute toxicity. Its industrial use is primarily regulated to minimize exposure and potential environmental impact.

InChI:InChI=1/C5H8N2/c6-5-2-1-3-7-4-5/h1-2,4,7H,3,6H2

Upstream product

• 13472-79-2 5-iodo-pyridin-2-ol 
• 5350-93-6 6-Chloro-pyridin-3-ylamine 
• 5418-51-9 5-nitro-2-hydroxypyridine 
• 33630-94-3 5-amino-2-hydroxypyridine 
• 24242-20-4 5-amino-pyridine-2-carboxylic acid 

Downstream Products

• 94805-52-4 6-hydroxy-3-pyridinecarbonitrile 
• 10261-82-2 1,5-naphthyridin-2(1H)-one 
• 71119-20-5 sulfanilic acid-(6-hydroxy-[3]pyridylamide) 
• 764717-60-4 6-methyl-1H-[1,5]naphthyridin-2-one 
• 33630-94-3 5-aminopyridin-2(1H)-one 
• 1293979-19-7 C₁₂H₈F₂N₂O₂ 
• 1208331-07-0 C₂₄H₁₉N₃O₂ 

Relevant articles and documents

The Lactam-Lactim Tautomerization of Monoamino-Substituted 2-Pyridinols in Tetrahydrofuran

MINDO/3 calculations have been performed on 3-amino-, 4-amino-, 5-amino-, and 6-amino-2-pyridinols to estimate their molecular geometries.The lactam-lactim tautomerization from amino-2-pyridone to amino-2-pyridinol was expected for 5-amino- and 6-amino-2-pyridinols from the MINDO/3 calculations.In addition, their dimer formation energies were evaluated by the CNDO/2 method.Among the four amino-2-pyridones, 6-amino-2-pyridone has the largest dimer formation energy and 3-amino-2-pyridone the smallest.Furthermore, to certify the tautomerization of 3-amino-, 5-amino-, and 6-amino-2-pyridinols the UV absorption and fluorescence spectra were measured, and compared with those of their O-methyl and nuclear N-methyl derivatives.From the UV spectral data the equilibrium constants of the lactam-lactim tautomerization were determined for 5-amino and 6-amino derivatives in tetrahydrofuran (THF) at various temperatures.The lactam form is more stable than that of the lactim; the enthalpy changes between two forms of 5-amino and 6-amino derivatives were estimated to be 7.9 and 6.3 kJ mol-1, respectively.The lactam and lactim dimers of these two derivatives were found to be easily formed in THF and ether.From the fluorescence spectral data the lactim dimer of 6-amino derivative was found to be formed in the lowest excited ?,?* singlet state.On the other hand, the 3-amino derivative exists predominantly in the lactam monomer form in both the ground and the lowest excited ?,?* singlet states.

SUBSTITUTED HYDANTOIN AND THIOHYDANTOIN DERIVATIVES AS ANDROGEN RECEPTOR ANTAGONISTS

Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I), wherein R1, R2a, R,2b,Z

SUBSTITUTED THIOHYDANTOIN DERIVATIVES AS ANDROGEN RECEPTOR ANTAGONISTS

Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: Formula (I) wherein R1 and G are defined herein.