59318-12-6

Basic information

• Product Name: di-morpholin-4-yl-phosphinic acid 3-amino-6-chloro-4-phenyl-quinolin-2-yl ester
• CAS NO: 59318-12-6
• Molecular Weight: 488.911
• Mol File: 59318-12-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: di-morpholin-4-yl-phosphinic acid 3-amino-6-chloro-4-phenyl-quinolin-2-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: di-morpholin-4-yl-phosphinic acid 3-amino-6-chloro-4-phenyl-quinolin-2-yl ester(59318-12-6)
• EPA Substance Registry System: di-morpholin-4-yl-phosphinic acid 3-amino-6-chloro-4-phenyl-quinolin-2-yl ester(59318-12-6)

Safety Data

• Hazardous Substances Data: 59318-12-6(Hazardous Substances Data)

Upstream product

• 7264-90-6 di-morpholin-4-yl-phosphinic acid chloride 
• 5220-83-7 3-amino-6-chloro-1,2-dihydro-2-oxo-4-phenylquinoline 

Downstream Products

• 59163-16-5 6-chloro-2-methylsulfanyl-4-phenyl-quinolin-3-ylamine 
• 59318-09-1 6-chloro-2-morpholin-4-yl-4-phenyl-quinolin-3-ylamine 

Relevant articles and documents

Phosphorylation of cyclic amides

Compounds of the general formula STR1 are reacted with a strong base followed by a phosphorylating agent, such as dicyclicaminophosphinic halide or bis-di-lower alkylaminophosphinic halide to produce an imine of the formula STR2 wherein R is dicyclicaminophosphinyloxy or bis-di-lower alkylaminophosphinyloxy. R represents a leaving group which will undergo nucleophilic displacement with nitrogen, oxygen, sulfur and carbon containing nucleophiles, that is, nucleophiles which have, as a reactive site, a nitrogen, oxygen, sulfur or carbon atom, such that, when the cyclic imine undergoes nucleophilic displacement, there is formed C--N, C--O, C--S and C--C bonds between the carbon atom of the cyclic imine and the nucleophilic group. The end products may be utilized as intermediates in the production of pharmaceutically valuable compounds and, in some instances, are pharmaceutically valuable compounds per se.