7264-90-6

Usage

Uses

Used in Pharmaceutical Industry:
DiMorpholinophosphinyl Chloride is used as a condensing reagent for the synthesis of Dexamethasone Phosphate (D298835), a pro-drug of Dexamethasone (D298800), an anti-inflammatory glucocorticoid. DMP aids in the formation of the ester bond between Dexamethasone and a phosphate group, enhancing the drug's water solubility and bioavailability, which in turn improves its therapeutic effects.

Upstream product

• 110-91-8 morpholine 
• 22630-09-7 trimorpholylmethane 
• 1498-57-3 morpholinophosphonic dichloride 
• 109-11-5 morpholine-3-one 
• 10025-87-3 trichlorophosphate 

Downstream Products

• 59349-95-0 3-(di-morpholin-4-yl-phosphinoyl)-3H-benzooxazol-2-one 
• 59349-92-7 di-morpholin-4-yl-phosphinic acid 2-phenyl-quinazolin-4-yl ester 
• 4441-12-7 tris(morpholino)phenylphosphine oxide 
• 59318-11-5 di-morpholin-4-yl-phosphinic acid 7-chloro-5-phenyl-3H-benzo[e][1,4]diazepin-2-yl ester 
• 95684-86-9 C₁₅H₂₃N₄O₃P 
• 95684-87-0 C₁₅H₂₂N₅O₅P 
• 59349-85-8 7-chloro-5-(2-chlorophenyl)-2-[bis-(morpholino)-phosphinyloxy]-3H-1,4-benzodiazepine 
• 59349-86-9 5-(2-chlorophenyl)-2-[bis(morpholino)phosphinyloxy]-7-nitro-3H-1,4-benzodiazepine 
• 59469-54-4 di-morpholin-4-yl-phosphinic acid 7-nitro-5-phenyl-3H-benzo[e][1,4]diazepin-2-yl ester 
• 85904-33-2 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1]benzazepine 
• 59468-20-1 7-(2-Methyl-1,3-dioxolan-2-yl)-2[bis(morpholino)phosphinyloxy] 5-phenyl-3H-1,4-benzodiazepine 
• 80033-27-8 6-(o-fluorophenyl)-1,4,4-trimethyl-8-nitro-4H-s-triazolo[4,3-a][1,4]benzodiazepine 
• 59468-03-0 di-morpholin-4-yl-phosphinic acid 7-chloro-5-(2-fluoro-phenyl)-3-methyl-3H-benzo[e][1,4]diazepin-2-yl ester 
• 59318-14-8 di-morpholin-4-yl-phosphinic acid 7-chloro-2-methylamino-3H-benzo[e][1,4]diazepin-5-yl ester 

Relevant academic research and scientific papers

METHOD FOR PREPARING 3-[(4S)-8-BROMO-1-METHYL-6-(PYRIDIN-2-YL)-4H-IMIDAZO[1,2-A][1,4]BENZODIAZEPIN-4-YL]-PROPIONIC ACID METHYL ESTER, AND COMPOUNDS USEFUL IN SAID METHOD

The present invention relates to a method for preparing 3- [ ( 4S ) -8-bromo-l-methyl-6- (pyridin-2-yl ) -4H-imidazo [1,2- a] [ 1, 4 ] benzodiazepin-4-yl ] -propionic acid methyl ester starting from 3- [ (3S) -7-bromo-2-oxo-5- (pyridin-2-yl ) -2, 3-dihydr

Preparation method of benzodiazepine derivatives

The invention relates to a preparation method of benzodiazepine derivatives. The preparation method comprises preparing a compound shown in the formula (III) from a compound shown in the formula (V),preparing a compound shown in the formula (II) through a reaction and finally preparing benzodiazepine derivatives shown in the formula (I) and their pharmaceutically acceptable salts. The invention also discloses an intermediate in the preparation process and a preparation method thereof. The preparation method shortens the reaction processes, improves the reaction yield, is simple, is easy to operate and control and is conducive to expanded production.

N,N'-Bis-morpholinophosphinic chloride as a coupling reagent in peptide synthesis

N,N'-bis-morpholinophosphinic chloride (BMP-Cl) has been successfully used as a coupling reagent for first time in the peptide synthesis.Few peptides have been prepared using this coupling reagent and the results have been compared with those obtained by anhydride method.

AMIDATION OF HALOGEN DERIVATIVES OF PHOSPHORUS WITH 4,4',4''-METHYLIDYNETRISMORPHOLINE

4,4'4''-Methylidynetrismorpholine amidates polyhalophosphorus compounds and is a more reactive agent than the previously studied N,N,N'N'-tetraalkylmethanediamines.The dimorpholinomethylium chloride formed as a result of the reaction does not react with the amidation products, which makes it possible to isolate them in a pure state.

Some Derivatives of Morpholinophosphorodichloridate and dichloridothioate

Morpholinophosphorodichloridate and dichloridothioate reacted with amines (2 molar equivalents) to give the amidic chlorides which were treated with nucleophilic reagents to give sixty-four derivatives.However the dichloridothioate with primary amines (1

PHOSPHORYLATION COMPETITIVE DE DERIVES D'UREES/THIOUREES ET DE CARBAMATES/THIOCARBAMATES EN RELATION AVEC LE MODELE O-PHOSPHOBIOTINE.

The phosphorylation of a number of heterocyclic substrates, such as ureas and carbamates, and their sulfur analogues, has been investigated with the object of clarifying previous results concerning the site of phosphorylation of this type of substrate, wh