7264-90-6

Basic information

• Product Name: DiMorpholinophosphinyl Chloride
• Synonyms: DiMorpholinophosphinyl Chloride;Phosphinic chloride, P,P-di-4-morpholinyl-;4-[chloro(morpholin-4-yl)phosphoryl]morpholine
• CAS NO: 7264-90-6
• Molecular Formula: C₈H₁₆ClN₂O₃P
• Molecular Weight: 254.651001
• Mol File: 7264-90-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 80 °C
• Boiling Point: 137-140 °C(Press: 0.02 Torr)
• Appearance: /
• Density: 1.36±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: -3.02±0.20(Predicted)
• Stability: Moisture Sensitive
• CAS DataBase Reference: DiMorpholinophosphinyl Chloride(CAS DataBase Reference)
• NIST Chemistry Reference: DiMorpholinophosphinyl Chloride(7264-90-6)
• EPA Substance Registry System: DiMorpholinophosphinyl Chloride(7264-90-6)

Safety Data

• Hazardous Substances Data: 7264-90-6(Hazardous Substances Data)

Usage

Uses

Dimorpholinophosphinyl Chloride is an condensing reagent in the synthesis of Dexamethasone Phosphate (D298835), a pro-drug of Dexamethasone (D298800), an anti-inflammatory glucocorticoid.

Upstream product

• 109-11-5 morpholine-3-one 
• 22630-09-7 trimorpholylmethane 
• 1498-57-3 morpholinophosphonic dichloride 
• 110-91-8 morpholine 
• 10025-87-3 trichlorophosphate 

Downstream Products

• 59349-95-0 3-(di-morpholin-4-yl-phosphinoyl)-3H-benzooxazol-2-one 
• 59349-92-7 di-morpholin-4-yl-phosphinic acid 2-phenyl-quinazolin-4-yl ester 
• 59318-12-6 di-morpholin-4-yl-phosphinic acid 3-amino-6-chloro-4-phenyl-quinolin-2-yl ester 
• 80033-27-8 6-(o-fluorophenyl)-1,4,4-trimethyl-8-nitro-4H-s-triazolo[4,3-a][1,4]benzodiazepine 
• 59469-54-4 di-morpholin-4-yl-phosphinic acid 7-nitro-5-phenyl-3H-benzo[e][1,4]diazepin-2-yl ester 
• 85904-33-2 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1]benzazepine 
• 59468-20-1 7-(2-Methyl-1,3-dioxolan-2-yl)-2[bis(morpholino)phosphinyloxy] 5-phenyl-3H-1,4-benzodiazepine 
• 59468-03-0 di-morpholin-4-yl-phosphinic acid 7-chloro-5-(2-fluoro-phenyl)-3-methyl-3H-benzo[e][1,4]diazepin-2-yl ester 
• 59318-14-8 di-morpholin-4-yl-phosphinic acid 7-chloro-2-methylamino-3H-benzo[e][1,4]diazepin-5-yl ester 
• 59349-86-9 5-(2-chlorophenyl)-2-[bis(morpholino)phosphinyloxy]-7-nitro-3H-1,4-benzodiazepine 
• 59349-85-8 7-chloro-5-(2-chlorophenyl)-2-[bis-(morpholino)-phosphinyloxy]-3H-1,4-benzodiazepine 
• 59349-90-5 5-chloro-2-(2-chloro-acetylamino)-N-(di-morpholin-4-yl-phosphinoyl)-benzamide 
• 82212-32-6 3-acetossi-7-cloro-5-fenil-2-(di-4-morfolinil)fosfinilossi-3H-1,4-benzodiazepina 
• 59318-11-5 di-morpholin-4-yl-phosphinic acid 7-chloro-5-phenyl-3H-benzo[e][1,4]diazepin-2-yl ester 

Relevant articles and documents

METHOD FOR PREPARING 3-[(4S)-8-BROMO-1-METHYL-6-(PYRIDIN-2-YL)-4H-IMIDAZO[1,2-A][1,4]BENZODIAZEPIN-4-YL]-PROPIONIC ACID METHYL ESTER, AND COMPOUNDS USEFUL IN SAID METHOD

The present invention relates to a method for preparing 3- [ ( 4S ) -8-bromo-l-methyl-6- (pyridin-2-yl ) -4H-imidazo [1,2- a] [ 1, 4 ] benzodiazepin-4-yl ] -propionic acid methyl ester starting from 3- [ (3S) -7-bromo-2-oxo-5- (pyridin-2-yl ) -2, 3-dihydr

N,N'-Bis-morpholinophosphinic chloride as a coupling reagent in peptide synthesis

N,N'-bis-morpholinophosphinic chloride (BMP-Cl) has been successfully used as a coupling reagent for first time in the peptide synthesis.Few peptides have been prepared using this coupling reagent and the results have been compared with those obtained by anhydride method.

Some Derivatives of Morpholinophosphorodichloridate and dichloridothioate

Morpholinophosphorodichloridate and dichloridothioate reacted with amines (2 molar equivalents) to give the amidic chlorides which were treated with nucleophilic reagents to give sixty-four derivatives.However the dichloridothioate with primary amines (1