5932-62-7Relevant academic research and scientific papers
New methylene homologation method for cyclic ketones
Liu, Huaqing,Sun, Chunrui,Lee, Nam-Kyu,Henry, Roger F.,Lee, Daesung
supporting information, p. 11889 - 11893 (2012/10/29)
Teaching new tricks to an old dog: By intercepting adducts between ketones and lithium trimethylsilyldiazomethane, a new Tiffeneau-Demjanov type methylene homologation could be realized in a single-step operation. Among proton sources and Lewis acids, silica gel was found to be the most effective reagent for the protonation of intermediates and their subsequent ring expansion (see scheme). Copyright
COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY
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Page/Page column 101, (2010/11/23)
The present invention provides compounds of Formula (I) (wherein R1, R3, X, W, Z and ring Y are as defined herein). The present invention also provides compositions comprising these compounds that are useful for treating cellular proliferative diseases or disorders associated with KSP kinesin activity and for inhibiting KSP kinesin activity.
Selective homologation of ketones and aldehydes with diazoalkanes promoted by organoaluminum reagents
Maruoka,Concepcion,Yamamoto
, p. 1283 - 1290 (2007/10/02)
Organoaluminum-promoted single homologation or ring expansion of ketones and aldehydes with diazoalkanes has been described, and among various organoaluminium reagents, exceptionally bulky methylaluminum bis(2,6-di-tert-butyl-4-methylphenoxide) (MAD) is found to be highly effective for the selective homologation of various ketones and aldehydes.
New Methods and Reagents in Organic Synthesis. 18. Homologation of Ketones with Trimethylsilyldiazomethane (TMSCHN2)
Hashimoto, Norio,Aoyama, Toyohiko,Shioiri, Takayuki
, p. 119 - 124 (2007/10/02)
Trimethylsilyldiazomethane (TMSCHN2) easily reacts with various ketones in the presence of boron trifluoride etherate in methylene chloride solution to give chain- or ring-homologated ketones, and can be used as a stable and safe substitute for hazardous diazomethane.The reaction proceeds below 0 deg C during 1-4 h, and permits much more efficient homologation than can be achieved with diazomethane.
NEW METHODS AND REAGENTS IN ORGANIC SYNTHESIS. 10. TRIMETHYLSILYLDIAZOMETHANE (TMSCHN2), A NEW, STABLE, AND SAFE REAGENT FOR THE HOMOLOGATION OF KETONES
Hashimoto, Norio,Aoyama, Toyohiko,Shiori, Takayuki
, p. 4619 - 4622 (2007/10/02)
Homologation of ketones can be achieved with trimethylsilyldiazomethane (TMSCHN2) which is a stable and safe substitute for hazardous diazomethane.
