593266-85-4Relevant academic research and scientific papers
New chemo-enzymatic approaches for the synthesis of (R)- and (S)-bufuralol
Nagy, Botond,Dima, Norbert,Paizs, Csaba,Brem, Jürgen,Irimie, Florin Dan,Toa, Monica Ioana
, p. 1316 - 1322 (2015/01/09)
Both enantiomers of bufuralol are pharmaceutically important molecules. While the (S)-isomer with a higher β-blocking activity is recommended for hypertension treatment, the (R)-enantiomer can be used as marker of hepatic activity. In this paper two new a
Asymmetric synthesis of (S)-bufuralol and a propafenone analogue
Zaidlewicz, Marek,Tafelska-Kaczmarek, Agnieszka,Prewysz-Kwinto, Andrzej,Chechlowska, Aldona
, p. 1659 - 1664 (2007/10/03)
Asymmetric synthesis of (S)-bufuralol of 87% ee from 3-ethyl-2-hydroxybenzaldehyde, via the reduction of 2-bromo-1-(7-ethylbenzofuran-2-yl)ethanone with (-)-B-chlorodiisopinocampheylborane as the key step, followed by cyclization of the product bromohydrin to the corresponding epoxide and treatment with tert-butylamine, is described. (S)-1-(3-Phenethylbenzofuran-2-yl)-2-propylaminoethanol of 73% ee, a propafenone analogue, was prepared following the same approach.
