593283-25-1

Upstream product

• 5948-71-0 4-(4-chlorophenyl)-5-(ethoxycarbonyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 593283-32-0 4-(4-chloro-phenyl)-5-[5-(4-chloro-phenyl)-4H-[1,2,4]triazol-3-yl]-6-methyl-3,4-dihydro-1H-pyrimidin-2-one 
• 1083098-31-0 C₁₄H₁₄ClN₅O₂ 
• 593283-33-1 4-(4-chloro-phenyl)-5-[5-(4-dimethylamino-phenyl)-4H-[1,2,4]triazol-3-yl]-6-methyl-3,4-dihydro-1H-pyrimidin-2-one 
• 593283-31-9 4-(4-chloro-phenyl)-6-methyl-5-[5-(3-nitro-phenyl)-4H-[1,2,4]triazol-3-yl]-3,4-dihydro-1H-pyrimidin-2-one 

Relevant academic research and scientific papers

Microwave assisted synthesis and characterization of some new annulated pyrimidinone derivatives

4-Aryl-6-methyl-2-pyrimidinone-5-carbohydrazide derivatives have been synthesized from the reaction of different dihydropyrimidinone with hydrazine hydrate. These compounds upon microwave irradiation undergo clean and facile cyclization with chloroacetamide, chloroacetyl chloride and triethylorthoformate and led to the formation of 3-(6-methyl-2-oxo-4-substituted phenyl-1,2,3,4-tetrahydropyrimidin-5-yl)-1,6-dihydro-1,2,4-triazin-5(2H)-one, 4-(6-methyl-2-oxo-4-substitutedphenyl-1,2,3,4-tetrahydropyrimidin-5-yl) tetrahydropyridazine-3,6-dione, 6-methyl-5-(5-oxo-4,5-dihydro-1H-pyrazol-4-yl)- 4-substitutedphenyl-3,4-dihydropyrimidin-2(1H)-one and their substituted derivatives respectively, in quantitative yield. Structures of these newly synthesized compounds were established on the basis of spectra and analytical data.

Synthesis and anti-microbial activity of some pyrimidine derivatives

4-Aryl-5-carboethoxy-6-methyl-1,2,3,4-tetrahydropyrimidin-2-ones have been synthesized from easily available starting materials. The carboethoxy group at the C5-position of the pyrimidine ring is converted to corresponding hydrazide which in turn is condensed with cyclising agents such as aromatic aldehydes, CS2 etc. to give fused heterocycles. The fused heterocycles are then subjected to phenacylation to give N3-phenacylpyrimido-heterocycles in excellent yield. In a slightly modified way, uracil derivatives are condensed with ethyl bromoacetate to give N3-β-ethoxycarbonyl derivatives. The hydrazide derivatives of these N3-β-ethoxycarbonyl derivatives subsequently react with 1,2-diketones to give corresponding pyrimido pyridazine derivatives.