5948-71-0

Basic information

• Product Name: 4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester
• Synonyms: 4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester;4-(4-chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-Pyrimidinecarboxylic acid ethyl ester;Ethyl 4-(4-chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate;ethyl 4-(4-chlorophenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate;-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate;Ethyl 4-(4-chlorophenyl)
• CAS NO: 5948-71-0
• Molecular Formula: C₁₄H₁₅ClN₂O₃
• Molecular Weight: 294.73
• Mol File: 5948-71-0.mol
• Article Data: 123

Chemical Properties

• Melting Point: 213-215 °C
• Boiling Point: 411.782°C at 760 mmHg
• Flash Point: 202.839°C
• Appearance: /
• Density: 1.257g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.548
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.16±0.70(Predicted)
• CAS DataBase Reference: 4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester(5948-71-0)
• EPA Substance Registry System: 4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester(5948-71-0)

Safety Data

• Hazardous Substances Data: 5948-71-0(Hazardous Substances Data)

Usage

Uses

4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in Laboratory research and development process and chemical production process.

Synthesis

Substituted benzaldehyde (6.617×10-3mmol; 1.0 equiv.) is mixed with slightly excess equivalent of urea (6.749×10-3mmol; 1.02 equiv.) and ethyl acetoacetate (6.749×10-3mmol; 1.02 equiv.) in the presence of catalytic concentration 1.0×10-4mmol of our synthesized dimeric pyridinium salts along with dry MeCN at ambient reaction condition from 6-33 min. reaction condition. Yield: 92%

InChI:InChI=1/C14H15ClN2O3/c1-3-20-13(18)11-8(2)16-14(19)17-12(11)9-4-6-10(15)7-5-9/h4-7,12H,3H2,1-2H3,(H2,16,17,19)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 104-88-1 4-chlorobenzaldehyde 
• 57-13-6 urea 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 21351-39-3 monocarbamide dihydrogen sulfate 
• 873-76-7 para-Chlorobenzyl alcohol 
• 13086-93-6 (acetyloxy)(4-chlorophenyl)methyl acetate 
• 674-82-8 4-methyleneoxetan-2-one 
• 64-17-5 ethanol 
• 17356-08-0 thiourea 
• 5315-86-6 4-chlorobenzaldehyde semicarbazone 
• 37580-81-7 1,2-bis(4-chlorophenyl)-1,2-ethandiol 
• 4254-20-0 4,4'-dichlorobenzoin 
• 55718-52-0 1,1'-((4-chlorophenyl)methylene)diurea 

Downstream Products

• 593283-25-1 4-(4-chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid hydrazide 
• 1012074-52-0 C₁₄H₁₄ClN₃O₄ 
• 1091820-63-1 ethyl 4-(4-chlorophenyl)-1,2-dihydro-6-methyl-2-oxopyrimidine-5-carboxylate 
• 749906-87-4 ethyl-6-(bromomethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1254330-74-9 C₁₉H₂₄ClN₃O₄ 
• 1254330-67-0 C₁₆H₁₉ClN₂O₄ 
• 1254330-70-5 ethyl 4-(4-chlorophenyl)-3-(ethoxymethyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1254330-87-4 C₁₅H₁₆ClN₅O₃ 
• 1394138-69-2 ethyl 1-butyl-4-(4-chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1394138-70-5 ethyl 4-(4-chlorophenyl)-6-methyl-1-octyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1394138-72-7 ethyl 4-(4-chlorophenyl)-1-hexadecyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 302821-62-1 ethyl 4-(4-chlorophenyl)-1,6-dimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1426902-85-3 ethyl 3-[({[(E)-4-chlorobenzylidene]amino}oxy)methyl]-6-methyl-2-oxo-4-(4-chlorophenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1448024-41-6 (E)-ethyl 4-(4-chlorophenyl)-3-cinnamyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 

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