593283-26-2

Upstream product

• 100-10-7 4-dimethylamino-benzaldehyde 
• 17994-62-6 4-(4-dimethylamino-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester 

Downstream Products

• 593283-34-2 4-(4-dimethylamino-phenyl)-6-methyl-5-[5-(3-nitro-phenyl)-4H-[1,2,4]triazol-3-yl]-3,4-dihydro-1H-pyrimidin-2-one 
• 593283-36-4 4-(4-dimethylamino-phenyl)-5-[5-(4-dimethylamino-phenyl)-4H-[1,2,4]triazol-3-yl]-6-methyl-3,4-dihydro-1H-pyrimidin-2-one 
• 593283-35-3 5-[5-(4-chloro-phenyl)-4H-[1,2,4]triazol-3-yl]-4-(4-dimethylamino-phenyl)-6-methyl-3,4-dihydro-1H-pyrimidin-2-one 

Relevant academic research and scientific papers

Microwave assisted synthesis and pharmacological screening of novel 6-Methyl-2-oxo-4-substituted 5-(5-Phenyl-1,3,4-oxadiazole-2-yl)-1,2,3, 4-tetrahydropyrimidines

A simple and efficient method has been developed for the synthesis of various 1,3,4-oxadiazole derivatives prepared from DHPM using microwave irradiation technique. The series of 1,3,4-oxadiazole-2-yl-1,2,3,4- tetrahydropyrimidine-2(1H)-one derivatives synthesized, were structurally confirmed by analytical and spectral data and evaluated for there lipoxygenase inhibitory and antibacterial activities. The results showed that this skeletal framework exhibited marked potency as lipoxigenase inhibition and antibacterial agents. The most active lipoxigenase inhibitor and antibacterial agent was 6-methyl-2-oxo-4-(p-nitrophenyl)-5-(5-phenyl-1,3,4-oxadiazole-2-yl)-1,2,3,4- tetrahydropyrimidine.

Synthesis and anti-microbial activity of some pyrimidine derivatives

4-Aryl-5-carboethoxy-6-methyl-1,2,3,4-tetrahydropyrimidin-2-ones have been synthesized from easily available starting materials. The carboethoxy group at the C5-position of the pyrimidine ring is converted to corresponding hydrazide which in turn is condensed with cyclising agents such as aromatic aldehydes, CS2 etc. to give fused heterocycles. The fused heterocycles are then subjected to phenacylation to give N3-phenacylpyrimido-heterocycles in excellent yield. In a slightly modified way, uracil derivatives are condensed with ethyl bromoacetate to give N3-β-ethoxycarbonyl derivatives. The hydrazide derivatives of these N3-β-ethoxycarbonyl derivatives subsequently react with 1,2-diketones to give corresponding pyrimido pyridazine derivatives.