17994-62-6

Basic information

• Product Name: ethyl 4-(4-(dimethylamino)phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• Synonyms: ethyl 4-(4-(dimethylamino)phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• CAS NO: 17994-62-6
• Molecular Formula: C₁₆H₂₁N₃O₃
• Molecular Weight: 303.35624
• Mol File: 17994-62-6.mol
• Article Data: 102

Chemical Properties

• Boiling Point: 443.7°C at 760 mmHg
• Flash Point: 222.1°C
• Appearance: /
• Density: 1.164g/cm³
• Vapor Pressure: 4.56E-08mmHg at 25°C
• Refractive Index: 1.557
• CAS DataBase Reference: ethyl 4-(4-(dimethylamino)phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-(4-(dimethylamino)phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate(17994-62-6)
• EPA Substance Registry System: ethyl 4-(4-(dimethylamino)phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate(17994-62-6)

Safety Data

• Hazardous Substances Data: 17994-62-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H21N3O3/c1-5-22-15(20)13-10(2)17-16(21)18-14(13)11-6-8-12(9-7-11)19(3)4/h6-9,14H,5H2,1-4H3,(H2,17,18,21)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 17356-08-0 thiourea 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 57-13-6 urea 
• 1703-46-4 N,N-dimethyl-4-hydroxymethylaniline 
• 4433-85-6 2-ethyl-3-oxobutanoic acid 

Downstream Products

• 1091859-64-1 C₁₆H₁₉N₃O₃ 
• 1122513-54-5 ethyl 6-[4-(dimethylamino)phenyl]-1-formyl-4-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1254120-69-8 C₂₃H₂₅N₃O₄ 
• 1402085-58-8 (E)-4-(4-dimethylaminophenyl)-6-(4-dimethylaminostyryl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid 
• 593283-34-2 4-(4-dimethylamino-phenyl)-6-methyl-5-[5-(3-nitro-phenyl)-4H-[1,2,4]triazol-3-yl]-3,4-dihydro-1H-pyrimidin-2-one 
• 593283-36-4 4-(4-dimethylamino-phenyl)-5-[5-(4-dimethylamino-phenyl)-4H-[1,2,4]triazol-3-yl]-6-methyl-3,4-dihydro-1H-pyrimidin-2-one 
• 593283-35-3 5-[5-(4-chloro-phenyl)-4H-[1,2,4]triazol-3-yl]-4-(4-dimethylamino-phenyl)-6-methyl-3,4-dihydro-1H-pyrimidin-2-one 
• 593283-26-2 4-(4-dimethylamino-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid hydrazide 

Relevant articles and documents

An efficient bakers' yeast catalyzed synthesis of 3,4-dihydropyrimidin-2-(1H)-ones

Bakers' yeast (Saccharomyces cerevisiae) efficiently catalyzes the three-component Biginelli reaction of aldehydes, β-keto esters, and urea/thiourea to form 3,4-dihydropyrimidin-2-(1H)-ones in good to excellent yields.

Hydrotalcite: A novel and reusable solid catalyst for one-pot synthesis of 3,4-dihydropyrimidinones and mechanistic study under solvent free conditions

Synthesis of 3,4-dihydropyrimidinones/thiones, a multicomponent synthesis using ethyl acetoacetate, substituted aromatic aldehydes, and urea/thiourea has been carried out in presence of Mg-Al-CO3 and Ca-Al-CO3 hydrotalcite as a reusa

Poly(N-vinyl-2-pyrrolidone)-supported ferric chloride: An effective reusable heterogeneous catalyst for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via three-component Biginelli reaction

An environmentally benign three-component Biginelli protocol for the one-pot synthesis of substituted 3,4-dihydropyrimidin-2(1H)-ones/thiones using an accessible, nontoxic, easy to handle, and recoverable macromolecular Lewis acidic catalyst is developed.

Efficient biocatalytic strategy for one-pot Biginelli reaction via enhanced specific effects of microwave in a circulating reactor

A one-pot efficient biocatalytic strategy for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones was developed in a circulating microwave reactor selecting α-chymotrypsin as the promiscuous biocatalyst. In the circulating reaction system, the combination o