5933-41-5

Upstream product

• 67-56-1 methanol 
• 13398-26-0 (S)-2-methyl-2-phenylglycine 
• 136032-88-7 C₁₄H₂₃NO₃ 
• 141236-02-4 2-[2-((S)-1-Hydroxy-ethyl)-4-oxo-4H-quinazolin-3-ylamino]-2-phenyl-propionic acid methyl ester 
• 145057-52-9 8-Methoxy-6,9-dimethyl-9-phenyl-8-trimethylsilanyloxy-9,10-dihydro-6H,8H-7-oxa-5,10,10a-triaza-cyclohepta[b]naphthalen-11-one 
• 13448-80-1 methyl R-(-)-atrolactate 
• 540485-22-1 (S)-N-(1-cyano-1-phenylethyl)-P,P-diphenylphosphinamide 
• 82572-06-3 P,P-diphenyl-N-(1-phenylethylidene)phosphinic amide 

Downstream Products

• 1034912-54-3 (S)-methyl 2-phenyl-2-(piperdin-1-yl)propanoate 
• 13398-26-0 (S)-2-methyl-2-phenylglycine 
• 1353629-04-5 C₁₀H₁₃NO₄S 
• 1353629-03-4 C₁₁H₁₅NO₄S 

Relevant academic research and scientific papers

SN2 displacement at the quaternary carbon center: A novel entry to the synthesis of α,α-disubstituted α-amino acids This Letter is dedicated to the late Professor Harry Wasserman, a great chemist as well as a splendid artist

A novel method for the SN2 reaction on quaternary carbon atoms using bis(p-nitrophenyl)phosphorazidate has been developed. Chiral tertiary alcohols were directly converted into the corresponding chiral tertiary azides with complete inversion of configuration. Several α,α-disubstituted α-amino esters or amino acids were prepared through the conversion of azides to the corresponding amines by catalytic hydrogenation.

COMPOUNDS AND METHODS FOR ANTIVIRAL TREATMENT

Compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections are provided. The compounds and compositions are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections

PYRAZOLO [1, 5 -A] PYRIMIDINES AS ANTIVIRAL AGENTS

The invention provides compounds of Formula I or Formula II: (I), (II) or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

Catalytic enantioselective Strecker reaction of ketoimines

A new method for the catalytic enantioselective Strecker reaction (cyanation) of N-diphenylphosphinoyl ketoimines is described. The asymmetric catalyst is a chiral gadolinium complex prepared from Gd(OiPr)3 and the d-glucose-derived ligand 3 in a 1:2 ratio. The reaction has a broad substrate generality, giving high enantioselectivity from aromatic, ethyl, primary alkyl, and α,β-unsaturated ketoimines. The products could be easily converted to disubstituted α-amino acids and their derivatives. Copyright

Aspartame dipeptide analogues: Effect of number of side-chain methylene group spacers and C(α)-methylation in the second position

Our model of the active site of the sweet taste receptor is shown to be consistent with the aspartame analogues in which the L-Phe2 residue is replaced by L-(αMe)Phg, L-(αMe)Phe or L-(αMe)Hph. The analogues containing either the first or the th

Amination with 3-acetoxyaminoquinazolin-4-(3H)ones: Preparation of α-aminoacid esters by reaction with silyl ketene acetals followed by N-N bond cleavage

Solutions of 3-acetoxyaminoquinazoline (5) react with enol ethers and silyl ketene acetals to give α-aminoaldehyde α-aminoketone or α-aminoacid derivatives. Acylation of the exocyclic nitrogen in these derivatives, as a preliminary to reductive N-N bond cleavage, could only be accomplished by indirect means. Samarium diiodide, however, effected the reduction of this N-N bond without the necessity for N-acylation. Solutions of the corresponding enantiopure 3-acetoxyaminoquinazolinone (34) brought about the disastereoselective amination of the prochiral silyl ketene acetal (15) and reductive N-N bond cleavage of the major disastereoisomer lead to enantiopure 2-phenylalanine methyl ester.

Synthese enantioselective d'α-aryl amino acides: subtitution nucleophile aromatique sur le fluorobenzene chrome tricarbonyle d'enolates chiraux

We report here a convenient synthesis of optically pure α-aryl amino acids by enantioselective substitution of fluorobenzene tricarbonylchromium using the Schiff bases of L-alanine methyl ester with (1R,2R,5R)-2-hydroxy-3-pinanone in presence of LDA or deprotonated 2-(tert-butyl)-4-methyl-1,3-oxazolidin-5 one.