59338-86-2

Usage

Uses

Used in Corrosion Inhibition:
Methyl 6-methoxy-1H-benzotriazole-5-carboxylate is used as a corrosion inhibitor to protect metal surfaces from degradation. Its application is crucial in various industries where metal components are exposed to corrosive environments, thus ensuring the longevity and performance of these components.
Used in Manufacturing of Plastics, Coatings, and Lubricants:
In the plastics, coatings, and lubricants industry, methyl 6-methoxy-1H-benzotriazole-5-carboxylate is used as an additive to enhance the stability and durability of these products. Its incorporation helps in maintaining the quality and performance of these materials over time, making them more reliable for various applications.
Used in Synthetic Resins and Rubbers Production:
Methyl 6-methoxy-1H-benzotriazole-5-carboxylate is utilized as an additive in the production of synthetic resins and rubbers to improve their overall stability and durability. This enhancement allows for the creation of more robust and long-lasting products that can withstand various conditions and requirements.
Overall, methyl 6-methoxy-1H-benzotriazole-5-carboxylate is a versatile chemical compound that plays a significant role in various industries due to its corrosion-inhibiting properties and its ability to improve the performance and stability of different materials.

InChI:InChI=1/C9H9N3O3/c1-14-8-4-7-6(10-12-11-7)3-5(8)9(13)15-2/h3-4H,1-2H3,(H,10,11,12)

Upstream product

• 59338-85-1 methyl-4,5-diamino-2-methoxybenzoate 
• 59338-92-0 6-methoxy-1H-benzotriazole-5-carboxylic acid 
• 59338-84-0 methyl 4-amino-2-methoxy-5-nitrobenzoate 

Relevant academic research and scientific papers

In vitro metabolic fate of alizapride: Evidence for the formation of reactive metabolites based on liquid chromatography-tandem mass spectrometry

The study of the formation of reactive metabolites during drug metabolism is one of the major areas of research in drug development since the link between reactive metabolites and drug adverse effects was well recognized. In particular, it has been shown that acrolein, a reactive carbonyl species sharing carbonylating and alkylating properties, binds covalently to nucleophilic sites in proteins, causing cellular damage. Alizapride, (±)-6-methoxy-N-{[1- (prop-2-en-1-yl)-pyrrolidin-2-yl] methyl}-1H-benzotriazole-5-carboxamide, is a N-allyl containing dopamine antagonist with antiemetic properties for which no data concerning its metabolic fate are so far reported. The study of the in vitro metabolism of alizapride showed the formation of acrolein during the oxidative N-deallylation. Moreover, the formation of an epoxide metabolite has been also described suggesting its role as a putative structural alert. The reactivity of the acrolein and the epoxide generated in alizapride metabolism was demonstrated by the formation of the corresponding adducts with nucleophilic thiols. Overall, ten metabolites have been identified and characterized by electrospray ionization tandem mass spectrometry analysis allowing to propose an in vitro metabolic scheme for alizapride. At the best of our knowledge, this is the second case of a drug involved in the generation of acrolein during its metabolism being the first represented by cyclophosphamide. Copyright

ARYL AND HETEROARYL-CARBOXAMIDE SUBSTITUTED HETEROARYL COMPOUNDS AS TYK2 INHIBITORS

Novel carboxamide substituted compounds of Formula (I) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Tyrosine Kinase 2 (Tyk2).