59339-61-6

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 7560-43-2 methyl 3-(4-methylphenyl)acrylate 
• 52916-86-6 (2RS,3SR)-2,3-dibromo-3-(4-methylphenyl)propanoic acid 

Downstream Products

• 182884-62-4 (Z)-2-bromo-3-(p-tolyl)propenoic acid 
• 182884-68-0 (Z)-methyl 2-bromo-3-(p-tolyl)propenoate 
• 140473-84-3 (E)-methyl 2-bromo-3-(p-tolyl)propenoate 
• 20754-20-5 3-p-tolyl-acrylic acid methyl ester 

Relevant academic research and scientific papers

PPh3O as an Activating Reagent for One-Pot Stereoselective Syntheses of Di- and Polybrominated Esters from Simple Aldehydes

(Chemical Equation Presented) An efficient one-pot method for the syntheses of di- and polybrominated esters from readily available aldehydes is reported. The direct use of the in situ generated byproduct PPh3O in the following reactions greatly improves the efficiency of the cascade. Also, the substrate scope of the reaction is proved to be broad.

Triphenylphosphine oxide-catalyzed stereoselective poly- and dibromination of unsaturated compounds

A novel PPh3O catalyzed bromophosphonium salt-mediated dibromination of α,β-unsaturated esters and β,γ- unsaturated α-ketoesters has been developed. The products were obtained with good to excellent yields and excellent diastereoselectivities.