59354-00-6

Basic information

• Product Name: 5-Iodo-1-(2’,3’,5’-tri-O-acetyl--D-ribofuranosyl)-imidazo-4-carbonitrile
• Synonyms: 5-Iodo-1-(2’,3’,5’-tri-O-acetyl--D-ribofuranosyl)-imidazo-4-carbonitrile
• CAS NO: 59354-00-6
• Molecular Formula: C₁₅H₁₆IN₃O₇
• Molecular Weight: 477.20791
• Product Categories: Bases & Related Reagents;Inhibitors;Nucleotides
• Mol File: 59354-00-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 136-138°C
• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Methanol
• CAS DataBase Reference: 5-Iodo-1-(2’,3’,5’-tri-O-acetyl--D-ribofuranosyl)-imidazo-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Iodo-1-(2’,3’,5’-tri-O-acetyl--D-ribofuranosyl)-imidazo-4-carbonitrile(59354-00-6)
• EPA Substance Registry System: 5-Iodo-1-(2’,3’,5’-tri-O-acetyl--D-ribofuranosyl)-imidazo-4-carbonitrile(59354-00-6)

Safety Data

• Hazardous Substances Data: 59354-00-6(Hazardous Substances Data)

Usage

Chemical Properties

Orange Powder

Uses

5-Iodo-1-(2’,3’,5’-tri-O-acetyl-β-D-ribofuranosyl)-imidazo-4-carbonitrile (cas# 59354-00-6) is a compound useful in organic synthesis.

Upstream product

• 23192-63-4 5-amino-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)imidazole-4-carbonitrile 
• 110-46-3 isopentyl nitrite 
• 23274-21-7 5-Amino-4-carbamoyl-1β-(2',3',5'-tri-O-acetyl-D-ribofuranosyl)imidazole 
• 2627-69-2 AICA riboside 

Downstream Products

• 126004-14-6 5-(3-hydroxy-1-propyn-1-yl)-1-β-D-ribofuranosylimidazole-4-carbonitrile 
• 118908-07-9 5-ethynyl-1-(β-D-ribofuranosyl)imidazole-4-carboxamide 
• 126004-13-5 5-ethynyl-1-β-D-ribofuranosylimidazole-4-carbonitrile 
• 126004-21-5 5-<(trimethylsilyl)-1-ethyn-1-yl>-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)imidazole-4-carbonitrile 
• 126004-18-0 5-(phenylethyn-1-yl)-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)imidazole-4-carbonitrile 
• 126004-19-1 5-(3-hydroxy-1-propyn-1-yl)-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)imidazole-4-carbonitrile 

Relevant articles and documents

Imidazole derivatives, process for production thereof, and use thereof

Disclosed are imidazole derivatives represented by formula [I]: STR1 wherein R is a hydrogen atom or STR2 wherein R2 is a hydrogen atom or a hydroxy protecting group, R2 protecting either a single hydroxy or two hydroxies together when R2 is a hydroxy protecting group, and R3 is a hydrogen atom or OR2 ; A is CONH2 or CN; and R1 is a hydrogen atom, lower alkyl, hydroxy lower alkyl, or phenyl. Also disclosed are six processes for producing these novel compounds among which a typical process comprises reacting a starting imidazole compound having a halogen at the 5-position thereof with an acetylene derivative to alkynylate the 5-position. Furthermore, the compounds having remarkable antitumor activities and therefore can provide novel antitumor agents.