59365-65-0Relevant academic research and scientific papers
Baker's yeast mediated stereoselective biotransformation of 1-acetoxy-3-aryloxypropan-2-ones
Egri, Gabriella,Kolbert, Attila,Balint, Jozsef,Fogassy, Elemer,Novak, Lajos,Poppe, Laszlo
, p. 271 - 283 (2007/10/03)
A series of 1-acetoxy-3-aryloxypropan-2-ones 1a-m were synthesized and subjected to biotransformation by baker's yeast yielding optically active monoacetates 5 or ent-5 and/or diols 4 of moderate to excellent enantiomeric purity. The dependence of the reduction/hydrolysis ratio and stereoselectivity on the size and substitution pattern of the aromatic moiety in the substrate is also discussed.
