5937-83-7

Usage

Uses

Used in Food Industry:
(4R)-4-Aminopentanoic acid is used as a flavor enhancer for its ability to stimulate the glutamate receptors on the tongue, providing a savory taste known as umami. This application is particularly prevalent in the production of monosodium glutamate (MSG), which is widely used in various cuisines to enhance the flavor of dishes.
Used in Pharmaceutical Industry:
(4R)-4-Aminopentanoic acid is used as a therapeutic agent for certain neurological conditions, such as Alzheimer's disease and other cognitive disorders. It is believed to help improve cognitive function by modulating the levels of glutamate in the brain, which is involved in memory and learning processes.
Used in Biochemical Research:
(4R)-4-Aminopentanoic acid is used as a research tool in the study of neurotransmission and synaptic plasticity. It is often employed in laboratory experiments to investigate the role of glutamate in the central nervous system and its potential implications in neurological disorders.
Used in Nutritional Supplements:
(4R)-4-Aminopentanoic acid is used as a dietary supplement to support the body's natural production of other amino acids and important molecules. It is often included in products designed to promote muscle growth, enhance cognitive function, and improve overall health.

Upstream product

• 17342-08-4 (S)-Pyroglutaminol 

Downstream Products

• 123993-05-5 methyl (R)-4-amino>pentanoate 
• 124020-64-0 methyl (R)-4-<α-<<6-<amino>ethyl>-N-<(o-nitrophenyl)thio>amino>methyl>-4-methoxy-2-pyridinyl>carbonyl>-erythro-β-tert-butoxy-L-histydyl>amino>pentanoate 
• 123993-14-6 (R)-4-<α-<<6-<amino>ethyl>-N-<(o-nitrophenyl)thio>amino>methyl>-4-methoxy-2-pyridinyl>carbonyl>-erythro-β-tert-butoxy-L-histydyl>amino>pentanoic acid 
• 123993-13-5 methyl (R)-4-<α-(benzyloxycarbonyl)-erythro-β-tert-butoxy-L-histidyl>amino>pentanoate 
• 123993-12-4 methyl (R)-4-<α-(benzyloxycarbonyl)-erythro-β-hydroxy-L-histidyl>amino>pentanoate 

Relevant academic research and scientific papers

A convenient synthesis of racemic and optically active 1-aza-1,3-dienes derived from γ-amino esters: Reduction to α,β-unsaturated and saturated γ-amino acid derivatives

A simple synthesis of racemic and optically active 1-azadienes derived from γ-amino esters by olefination reaction of alkyl glyoxylates and functionalized phosphonium salts or phosphine oxides is reported. Selective reduction of these 1-azadienes with hydrides yields (E)-γ-amino-α,β-unsaturated esters. A simple procedure for the preparation of saturated γ-amino acids and γ-amino esters from the previously synthesized vinylogous amino esters is also described.

Man-designed bleomycin with altered sequence specificity in DNA cleavage

The synthetic approach to the concerted antitumor mechanism of bleomycin is studied by introducing a dynamic change into the O2-activation moiety and DNA-binding site. A model PYML(6)-bleomycin previously reported, possessing an oxygen-activating methoxypyridine moiety and a DNA-binding bithiazole moiety, exhibits a nucleotide cleavage mode virtually identical with that of bleomycin. Herein reported is a newly designed bleomycin analogue, PYML(6)-(4R-APA)-distamycin, wherein the 4-methoxypyridine moiety and a DNA-binding distamycin component are connected through an (R)-4-aminopentanoic acid linker moiety. Synthesis of PYML(6)-(4R-APA)-distamycin is carried out by condensation of the hydroxyhistidine-pentatoic acid fragment with the methoxypyridien moiety, followed by introducing of the distamycin moiety. PYML(6)-(4R-APA)-distamycin cleaves a G4 phage DNA fragment (100 base pairs) at 1 μM concentration in the presence of Fe(II), oxygen, and dithiothreitol and induces dramatically altered adenine/thymine specificity. It is indicated that the specific recognition of base sequences for the cleavage is mainly controlled by the DNA affinity site and that the (R)-4-aminopentanoic acid linker seems to determine the proper arrangement of the iron-oxygen site and the distamycin moiety on DNA.