123993-14-6Relevant articles and documents
Man-designed bleomycins: Significance of the binding sites as enzyme models and of the stereochemistry of the linker moiety
Owa, Takashi,Haupt, Andreas,Otsuka, Masami,Kobayashi, Susumu,Tomioka, Nobuo,Itai, Akiko,Ohno, Masaji,Shiraki, Takashi,Uesugi, Motonari,Sugiura, Yukio,Maeda, Kenji
, p. 1193 - 1208 (2007/10/02)
Comparison of the DNA cleavage activity of man-designed bleomycins demonstrates that belomycins are small enzymes comprised of a catalytic site and a binding site. The linker moiety is shown to be significant for DNA binding, and inversion of its stereoch