59378-12-0

Upstream product

• 1125-99-1 1-(1-Cyclohexen-1-yl)pyrrolidine 
• 2882-19-1 ethyl 2-phenyl-2-bromoacetate 
• 1141378-30-4 (E)-2-(1,3-diphenylallyl)cyclohexanone 
• 108-94-1 cyclohexanone 

Downstream Products

• 97800-07-2 methyl 2-(2-oxocyclohexyl)-2-phenylacetate 
• 59378-13-1 1-(4-hydroxyphenyl)-2-oxo-3-phenyl-2,4,5,6,7,7a-hexahydro-indole 
• 1579255-55-2 C₁₇H₂₂O₂S₂ 

Relevant academic research and scientific papers

Hydrogen-bond-activated palladium-catalyzed allylic alkylation via allylic alkyl ethers: Challenging leaving groups

C-O bond cleavage of allylic alkyl ether was realized in a Pd-catalyzed hydrogen-bond-activated allylic alkylation using only alcohol solvents. This procedure does not require any additives and proceeds with high regioselectivity. The applicability of this transformation to a variety of functionalized allylic ether substrates was also investigated. Furthermore, this methodology can be easily extended to the asymmetric synthesis of enantiopure products (99% ee).

1-Aryl-2-oxo-2,4,5,6,7,7a-hexahydro-indoles, salts, pharmaceutical compositions and methods of use

This invention relates to 1-aryl-2-oxo-2,4,5,6,7,7a-hexahydro-indoles, and acid addition salts thereof. In particular, the compounds have (β-aminoethoxy- or γ-amino-propoxy)-phenyl substituents, the amino groups in each case either being joined to two C1-5 alkyl groups or forming part of a heterocyclic group such as a pyrolidino, piperidino or morpholino group. Compounds in accordance with the invention have been found to exhibit interesting actions on the cardiovascular system in particular as vasodilators.