59381-13-4Relevant academic research and scientific papers
Stereochemical Studies of the 4-Alkyl-4-Arylpiperidine Class of Opioid Ligand
Casy, A. F.,Dewar, G. H.,Al-Deeb, Omar A. A.
, p. 964 - 972 (1989)
The (1)H (270, 400 MHz) and (13)C (67.5 MHz) NMR spectra of some 4-methyl- (also 4-n-propyl- and -isobutyl)-4-(3-hydroxy- and 3-methoxy-phenyl)piperidines and their 3-methyl diastereoisomers are reported.Many of the compounds had opioid ligand activities.The data were analysed in terms of preferred conformation and configuration (3-methyl derivatives).Only compounds with preference for axial 4-aryl chair conformations displayed marked agonist properties and the one potent antagonist, cis-1,3,4-trimethyl-4-(3-hydroxyphenyl)piperidine, favoured an equatorial 4-aryl chair. KEY WORDS 4-Alkyl-4-arylpiperidines Opioid ligands (1)H NMR (13)C NMR Stereochemistry Conformational analysis
Analgesic method using 1,3,4-trisubstituted-4-arylpiperidines
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, (2008/06/13)
1,3,4-Trisubstituted-4-arylpiperidines are used to impart analgesia and to treat narcotic addiction.
1,3,4-Trisubstituted-4-arylpiperidines and their preparation
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, (2008/06/13)
Novel 1,3,4-trisubstituted-4-arylpiperidines are prepared by alkylating a 2,3-disubstituted-3-arylpyrroline to afford a 1,2,3-trisubstituted-3-aryl-1-pyrrolinium salt, reacting the salt with diazomethane to provide a 1,2,3-trisubstituted-3-aryl-1,2-methyl
