59396-44-0

Usage

Uses

Used in Pharmaceutical Industry:
(4-chlorophenyl)(2-fluorophenyl)methanone is used as a building block for the synthesis of various pharmaceutical compounds. Its unique chemical structure, which includes a chlorine and fluorine atom on adjacent benzene rings, contributes to its utility in creating a range of medicinal agents.
Used in Organic Synthesis:
In the field of organic synthesis, (4-chlorophenyl)(2-fluorophenyl)methanone serves as an important intermediate for the creation of diverse chemical products. Its structural features facilitate its involvement in numerous chemical reactions, making it a valuable component in the synthesis of various compounds.
It is crucial to handle and store (4-chlorophenyl)(2-fluorophenyl)methanone with caution, as it may present health risks if mismanaged.

Upstream product

• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 393-52-2 2-Fluorobenzoyl chloride 
• 65214-60-0 4-chloro-α-(2-fluorophenyl)benzenemethanol 
• 106-39-8 bromochlorobenzene 
• 446-52-6 2-Fluorobenzaldehyde 
• 108-90-7 chlorobenzene 

Downstream Products

• 1227180-50-8 3-(4-chlorophenyl)benzo[d]isoxazole 
• 1374583-51-3 (4-chlorophenyl)(2-fluorophenyl)pyrimidin-5-yl methanol 
• 1374583-60-4 (4-chlorophenyl)(2-fluorophenyl)pyrimidin-3-yl methanol 
• 65214-60-0 4-chloro-α-(2-fluorophenyl)benzenemethanol 
• 3801-48-7 4-Chlor-2'-fluor-diphenyl-methan 

Relevant academic research and scientific papers

Continuous flow synthesis of diaryl ketones by coupling of aryl Grignard reagents with acyl chlorides under mild conditions in the ecofriendly solvent 2-methyltetrahydrofuran

An efficient continuous flow sequential synthesis of diaryl ketones was achieved by coupling of aryl Grignard reagents with acyl chlorides in the bio-derived “green” solvent 2-methyltetrahydrofuran (2-MeTHF) under mild reaction conditions (ambient temperature, 1 hour), allowing a safe and on-demand generation of 2-(3-benzoylphenyl)propionitrile with a productivity of 3.16 g hour?1

Method of utilizing continuous flow microreactor to synthesize benzophenone derivative

The invention belongs to the technical field of organic synthesis, and particularly relates to a method of utilizing a continuous flow microreactor to synthesize a benzophenone derivative. The methodincludes: using aryl Grignard reagent and acyl chloride as raw materials; at normal temperature, continuously synthesizing the benzophenone derivative in the microreactor; recycling a reaction solvent2-methyl tetrahydrofuran. Problems of environmental pollution and reaction operation safety caused by the fact that conventional Fridel-Crafts reaction is excessively dependent on reagents like aluminum trichloride, ferric trichloride and zinc dichloride are avoided, the defect that novel catalytic processes are expensive in catalytic reagent and harsh in operation condition is made up, and continuous synthesis of a medical intermediate ketoprofen nitrile is realized efficiently. The method has the advantages of high operation convenience, high reaction safety, high yield, high efficiency andreaction solvent reusability and is environment-friendly and efficient.

Elemental step thermodynamics of various analogues of indazolium alkaloids to obtaining hydride in acetonitrile

A series of analogues of indazolium alkaloids were designed and synthesized. The thermodynamic driving forces of the 6 elemental steps for the analogues of indazolium alkaloids to obtain hydride in acetonitrile were determined using an isothermal titration calorimeter (ITC) and electrochemical methods, respectively. The effects of molecular structure and substituents on the thermodynamic driving forces of the 6 steps were examined. Meanwhile, the oxidation mechanism of NADH coenzyme by indazolium alkaloids was examined using the chemical mimic method. The result shows that the oxidation of NADH coenzyme by indazolium alkaloids in vivo takes place by one-step concerted hydride transfer mechanism.

Analogues of fenarimol are potent inhibitors of trypanosoma cruzi and are efficacious in a murine model of chagas disease

We report the discovery of nontoxic fungicide fenarimol (1) as an inhibitor of Trypanosoma cruzi (T. cruzi), the causative agent of Chagas disease, and the results of structure-activity investigations leading to potent analogues with low nM IC50s in a T. cruzi whole cell in vitro assay. Lead compounds suppressed blood parasitemia to virtually undetectable levels after once daily oral dosing in mouse models of T. cruzi infection. Compounds are chemically tractable, allowing rapid optimization of target biological activity and drug characteristics. Chemical and biological studies undertaken in the development of the fenarimol series toward the goal of delivering a new drug candidate for Chagas disease are reported.

A novel Br?nsted acid catalyst for Friedel-Crafts acylation

Bis(trifluoroalkylsulfonylimino)trifluoromethanesulfonic acid has demonstrated remarkable catalytic ability in the electrophilic acylation of aromatic substrates. Various perfluoroalkyl substituted aroyl chlorides are employed in Friedel-Crafts acylation typically using 1 mol % of catalyst. Crown Copyright