593960-46-4Relevant academic research and scientific papers
2-Alkyloxazoles as potent and selective PI4KIIIβ inhibitors demonstrating inhibition of HCV replication
Keaney, Erin P.,Connolly, Michael,Dobler, Markus,Karki, Rajeshri,Honda, Ayako,Sokup, Samantha,Karur, Subramanian,Britt, Shawn,Patnaik, Anup,Raman, Prakash,Hamann, Lawrence G.,Wiedmann, Brigitte,Lamarche, Matthew J.
, p. 3714 - 3718 (2014/09/17)
Synthesis and SAR of 2-alkyloxazoles as class III phosphatidylinositol-4- kinase beta (PI4KIIIβ) inhibitors is described. These compounds demonstrate that inhibition of PI4KIIIβ leads to potent inhibition of HCV replication as observed in genotype (GT) 1a and 1b replicon and GT2a JFH1 virus assays in vitro.
5-PHENYLTHIAZOLE DERIVATIVES AND USE AS PI3 KINASE INHIBITORS
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Page/Page column 45, (2010/02/07)
Compounds of Formula I in free or salt form, wherein R1,R2,R3,R4, and R5, have the meanings as indicated in the specification, are useful for treating diseases mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
