593960-79-3

Upstream product

• 593959-27-4 5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-ylamine 
• 530-62-1 1,1'-carbonyldiimidazole 
• 34036-07-2 3,4 difluorobenzaldehyde 
• 593960-59-9 1-bromo-1-(3-fluoro-4-methanesulfonyl-phenyl)-propan-2-one 
• 593960-57-7 2-fluoro-1-methanesulfonyl-4-(2-nitro-propenyl)-benzene 
• 593960-58-8 1-(3-fluoro-4-methanesulfonyl-phenyl)propan-2-one 
• 254878-95-0 3-fluoro-4-(methylsulfonyl)benzaldehyde 

Downstream Products

• 957209-68-6 NVP-QAV₅₇₂ 

Relevant academic research and scientific papers

Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway

Using a parallel synthesis approach to target a non-conserved region of the PI3K catalytic domain a pan-PI3K inhibitor 1 was elaborated to provide alpha, delta and gamma isoform selective Class I PI3K inhibitors 21, 24, 26 and 27. The compounds had good cellular activity and were selective against protein kinases and other members of the PI3K superfamily including mTOR and DNA-PK.

5-PHENYL-THIAZ0L-2-YL-UREA DERIVATIVES AND USE AS PI3 KINASE INHIBITORS

The present invention concerns a compound of formula Ia wherein: Ra * is hydrogen or C1-C4-alkyl; Rb* is -(C1-C4-alkylene)-Y-C1-C4-haloalkyl or -(C1-C4

ORGANIC COMPOUNDS

Compounds of Formula (I); in free or salt form, wherein Ra, Rb, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

5-PHENYLTHIAZOLE DERIVATIVES AND USE AS PI3 KINASE INHIBITORS

Compounds of Formula I in free or salt form, wherein R1,R2,R3,R4, and R5, have the meanings as indicated in the specification, are useful for treating diseases mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.