59398-91-3

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-CHLORO-PHENYL)-OXAZOLE-4-CARBALDEHYDE is used as a building block for the synthesis of biologically active molecules, contributing to the development of new pharmaceuticals. Its unique structure allows for the creation of compounds with potential therapeutic effects, making it an essential component in drug discovery processes.
Used in Organic Synthesis:
In the field of organic synthesis, 2-(4-CHLORO-PHENYL)-OXAZOLE-4-CARBALDEHYDE is utilized as a key intermediate. Its reactivity and functional groups enable the formation of a wide range of organic compounds, facilitating advancements in chemical research and the production of novel materials.

Upstream product

• 22091-36-7 4-chloromethyl-2-(4-chlorophenyl)oxazole 
• 300800-07-1 methyl 2-(4-chlorophenyl)-1,3-oxazole-4-carboxylate 
• 22087-22-5 [2-(4-chloro-phenyl)-oxazol-4-yl]-methanol 
• 104-88-1 4-chlorobenzaldehyde 
• 26086-60-2 2-azido-4'-chloroacetophenone 
• 536-38-9 4-chlorobenzoylmethyl bromide 

Downstream Products

• 59398-96-8 5-bromo-2-(4-chloro-phenyl)-oxazole-4-carbaldehyde 

Relevant academic research and scientific papers

2-AMINO-BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS 5-LIPOXYGENASE AND/OR PROSTAGLANDIN E SYNTHASE INHIBITORS

The present invention relates to benzimidazole derivatives having the general formula I, wherein n is 0 or 1; X1 and X2 are independently, at each occurrence, CR5 or N; Y is C1-C6 alkylene, wherein alkylene is optionally substituted with one to two C1-C3 alkyl groups; R1 is selected from the group consisting of hydrogen, halogen, C1-C6 alkoxy, -NH2, -NHR6, -NR7R8 and -NH-(R9)n-R10, n being 0 or 1; R2 is selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, -NH2, -NHR6, - NR7R8 and -NH-(R9)n-R10; R3 is selected from the group consisting of hydrogen, hydroxyl, OR11, -NR7R8, C1-C6 alkoxy, C1-C6 alkyl, C3-C10 cycloalkyl, C1-C3 haloalkyl, -C(O)NHR11, aryl, heteroaryl and heterocyclyl, wherein each of said cycloalkyl, aryl, heteroaryl and heterocyclyl is optionally and independently substituted with one to four Ra groups; and R4 is selected from the group consisting of -NH2, -N(R12)(V)pR13, - NH(V)p-OR14, -NHC(O)R15, and groups of formula la shown below, and their use in the treatment of diseases, in particular inflammatory diseases, cancer, stroke and/or Alzheimer's disease.

Thermal rearrangement of azido ketones into oxazoles via azirines: One-pot, metal-free heteroannulation to functionalized 1,3-oxazoles

α-Azidoacetophenones were converted into 2-aryl-1,3-oxazole-4- carbaldehydes through rearrangement of the carbon framework upon exposure to DMF/POCl3. The unprecedented rearrangement occurs via alkenyl azides and 2H-azirines. A mechanism for this unusual reaction was proposed and evidenced.