59404-81-8Relevant academic research and scientific papers
Amino-modified Merrifield resins as recyclable catalysts for the safe and sustainable preparation of functionalized α-diazo carbonyl compounds
Fantinel, Mariane,Valiati, Nayara,Moro, Pedro A.M.,Sá, Marcus M.
, (2021/03/30)
Amino-functionalized polystyrene polymers derived from Merrifield resins were prepared and characterized. These basic materials were successfully employed as heterogeneous catalysts in the diazo transfer reaction to 1,3-dicarbonyl compounds, furnishing the corresponding diazo compounds in good to excellent yields and in relatively short reaction times. In addition, the work-up and purification protocols are simple and do not generate large amounts of waste, which are important features in sustainable catalysis and environmentally benign processes. The feasibility of the recovery and reuse of the amino-modified catalysts was also verified, since they can be employed up to five times without appreciable loss of catalytic activity. This straightforward procedure can be readily scaled up to gram scale, enabling the wide application of this method. The synthetic potential was demonstrated through the two-step preparation of 2-amino-N-dodecylacetamide (ANDA), a small molecule of commercial relevance.
METHOD FOR SYNTHESIZING ONE-DIMENSIONAL HELICAL NANOPOROUS STRUCTURES AND METHOD FOR SYNTHESIZING GLYCINE-DERIVED SURFACTANT FOR SYNTHESIZING HELICAL NANOPOROUS STRUCTURES
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Page/Page column 15, (2009/12/05)
Disclosed herein are a method for synthesizing one-dimensional helical mesoporous structure, in which a self-assembled structure of a glycine-derived surfactant is used as a template at room temperature to synthesize the one-dimensional helical mesoporous silica structures having a uniform pore size and a method for synthesizing a glycine-derived surfactant for synthesizing the helical nanoporous structures, in which relatively expensive surfactant can be easily recovered using an organic solvent and reused, which provides economical and environment friendly effects and the glycine-derived surfactant is synthesized by homogeneously heating a reaction product of glycine and phthalic anhydride by dielectric heating with irradiation of microwave, whereby it is possible to realize high yield of the glycine-derived surfactant, shortened synthesis time and increase in energy efficiency, leading to improvement in productivity and reduction in production cost.
Alkyl-substituted amino acid amides and analogous di- and triamines: New non-peptide G protein activators
Leschke, Christian,Storm, Rüdiger,Breitweg-Lehmann, Evelyn,Exner, Torsten,Nürnberg, Bernd,Schunack, Walter
, p. 3130 - 3139 (2007/10/03)
Synthesis and pharmacological properties of new potent direct activators of heterotrimeric G proteins are described. Compounds were synthesized from protected amino acids with alkylamines using coupling reagents (CDI, DCC, and EDC). Alkyl-substituted amino acid amides and their corresponding di- and triamines were subjected to structure-activity analysis. All compounds activated membrane-bound HL-60 GTPases in a pertussis toxin-sensitive fashion. This suggests a specific effect of compounds on the carboxy terminus of a defined subclass of heterotrimeric G proteins, i.e., members of the Gα(i) subfamily. Elongation of the alkyl chain and increasing the number of amino groups enhanced the potency of compounds on HL-60 membranes-bound GTPase. N-(2,5-Diaminopentyl)dodecylamine (21) was selected to study its mode of action employing purified pertussis toxin-sensitive G proteins. It stimulated Cα subunits by inducing the release of bound GDP. In contrast to receptors Gβγ complexes were not required for 21-mediated activation of Gα. Moderate isoform selectivity of its action was observed within a group of highly homologous members of the G(i) subfamily with Gα(o1) being activated at lowest concentrations, whereas higher concentrations were necessary for the stimulation of Gα(i1) or transducin. We conclude that these compounds represent important tools for studying G protein-dependent cellular functions.
Lyotropic Lipo-Amino-Acids: Synthesis and Structural Study
Gallot, B.,Hassan, H. Haj
, p. 195 - 214 (2007/10/02)
Lyotropic lipo-amino-acids Cn(AA) where AA is one of the following amino-acids: glycine, alanine, sarcosine, serine, tyrosine, lysine, hydroxyethylglutamine, hydroxypropylglutamine, hydroxypentylglutamine and glutamic acid, and Cn is a paraffinic chain with 12 or 18 carbon atoms have been synthesized.The study by X-ray diffraction of the lipo-amino-acids in concentrated water solution and in the anhydrous state has shown the existence of two types of mesophases: lamellar and hexagonal.The respective influence of the water concentration, the nature of the amino-acid and the length of the paraffinic chain on the domain of stability of the mesophases and on the values of their structural parameters has been established.
2,3-Substituted-1,2,5-thiadiazolium salt antimicrobials
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, (2008/06/13)
2-R1 -Substituted-3-amino-R2 -substituted-1,2,5-thiadiazolium salts have broad spectrum antibacterial and antifungal activity. They are useful for cleansing inanimate surfaces as well as agents for agriculture.
