59435-85-7

Usage

InChI:InChI=1/C6H10N2O3/c1-5(9)11-6-3-2-4-8(6)7-10/h6H,2-4H2,1H3

Upstream product

• 5724-81-2 1-pyrroline 
• 563-63-3 silver(I) acetate 
• 228397-30-6 1-nitroso-3,4-dihydro-2H-pyrrolium 

Downstream Products

• 33125-39-2 4-(2-amino-6-oxo-1,6-dihydro-purin-7-yl)-butyric acid 
• 163088-94-6 N²-(tetrahydrofuran-2-yl)deoxyguanosine 
• 5371-52-8 2-hydroxytetrahydrofuran 
• 7653-39-6 2-(2-hydroxypropyl)-4-hydroxy-6-methyl-1,3-dioxane 
• 85405-01-2 (6S)-3-(2-deoxy-β-D-erythro-pentofuranosyl)-8-hydroxy-6-methyl-5,6,7,8-tetrahydropyrimido[1,2-a]purin-10(3H)-one 
• 375345-24-7 N²-(4-hydroxybutyl)deoxyguanosine 

Relevant academic research and scientific papers

Synthesis of α-acetoxy-N-nitroso-4[3H]-pyrrolidine

Tritium labeled α-acetoxy-N-nitroso-4[3H]-pyrrolidine 3, an important model compound used in the study of the metabolism of nitrosopyrrolidine, has been prepared from commercially available 4[3H]-l-proline. The synthesis involves two steps; first the nitrosation of the aminoacid to N-nitroso-4[3H]-l-proline 2, followed by the oxidative decarboxylation with lead tetraacetate in dichloromethane with 1.2 equivalents of pyridine to α-acetoxy-N-nitroso-4[3H]-pyrrolidine in 23% overall yield. The compound was further purified by HPLC.

Cyclic α-acetoxynitrosamines: Mechanisms of decomposition and stability of α-hydroxynitrosamine and nitrosiminium ion reactive intermediates

A study of the kinetics and mechanism of the decay of α-acetoxy-N- nitrosopyrrolidine and α-acetoxy-N-nitrosopiperidine are reported. The compounds differ in reactivity by more than 2 orders of magnitude at physiological pH. On the basis of thermodynamic

The Chemistry of Nitrosamines, IV. - Syntheses of α-C-Functionalized N-Nitrosodialkylamines: Esters and Ethers of 1-alcohols

Imines (Schiff's bases) and nitrosyl chloride react to give N-alkyl-1-chloro-N-nitrosoalkylamines 13.Nucleophilic substitution by acetate or p-nitrobenzoate affords the acetates 7 and 9 and p-nitrobenzoates 8 and 10, respectively.The spectroscopic and chemical data of the newly synthesized compounds are discussed.