5944-40-1Relevant academic research and scientific papers
Cross-conjugated Trienamine Catalysis with α′-Alkylidene 2-Cyclohexenones: Application in β,γ-Regioselective Aza-Diels–Alder Reaction
Zhou, Zhi,Wang, Zhou-Xiang,Ouyang, Qin,Xiao, Wei,Du, Wei,Chen, Ying-Chun
, p. 2945 - 2949 (2017)
Endo-type cross-conjugated trienamines between highly congested α′-alkylidene 2-cyclohexenones and a chiral primary amine catalyst serve as HOMO-raised dienophiles in inverse-electron-demand aza-Diels–Alder cycloadditions with a number of 1-azadiene substrates. The reactions exhibit exclusive β,γ-regioselectivity, and multifunctional products with high molecular complexity are efficiently constructed in excellent diastereo- and enantioselectivity (>19:1 d.r., up to 99 % ee).
